MRC Laboratory of Molecular Biology: Recent submissions
Now showing items 5-8 of 98
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The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondii
The research presented in this thesis investigates the function of interferon gamma in vacuoles, namely Salmonella enterica serovar Typhimurium and Toxoplasma gondii. IFN-γ is a cytokine that functions in both the innate ... -
Principles of COPII Coat Assembly
Protein secretion in eukaryotic cells begins with COPII-mediated transport from the endoplasmic reticulum (ER). The COPII coat assembles on the cytoplasmic side of the ER membrane in consecutive stages. The inner coat ... -
Structural and Biochemical Investigation of the Pan2-Pan3 Deadenylase Complex
Almost all mature eukaryotic mRNAs contain a 3′ polyadenosine (poly(A)) tail, which promotes nuclear export of mRNAs, protects transcripts from exonucleolytic decay, and increases translation efficiency. As the poly(A) ... -
The bacterial actin-like cell division protein FtsA forms antiparallel double filaments upon binding of FtsN
Cell division is essential for the propagation of all living organisms. In the vast majority of bacteria, cell division is carried out by the divisome, a multiprotein machine spanning the cell envelope. The divisome performs ...
