MRC Laboratory of Molecular Biology: Recent submissions
Now showing items 5-8 of 60
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The mechanism of Parkin activation by PINK1 phosphorylation
(2020-05-16)Mutations in the E3 Ub ligase Parkin (PARK2) and the protein kinase PINK1 (PARK6) are genetically linked to Young-Onset Parkinson’s Disease. The two enzymes orchestrate clearance of damaged, cytotoxic mitochondria through ... -
Reorganization of mitochondrial architecture during apoptosis and mitophagy as investigated by correlative microscopy
(2020-07-17)In this thesis, I detail the use of various forms of correlative microscopy to investigate reorganization of mitochondrial architecture during two processes, apoptosis and mitophagy, in an effort to better understand the ... -
The ubiquitin coat of cytosol-invading bacteria
(2019-10-26)Cytosol-invading Salmonella enterica serovar Typhimurium are labelled with a ubiquitin coat, which serves the dual purpose of targeting bacteria to autophagy-mediated degradation and locally inducing pro-inflammatory ... -
Substrate recognition by the 26S proteasome
(2020-05-16)The 26S proteasome is a large protein complex found in all eukaryotes. It controls the degradation of a wide range of proteins in the cell, and thus it is crucial for homeostasis, regulated cell division and apoptosis. It ...
