Theses - MRC Laboratory of Molecular Biology: Recent submissions
Now showing items 5-8 of 140
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Structure and activation of the class D GPCR dimer Ste2
G protein-coupled receptors (GPCRs) are eukaryotic membrane proteins that perform a broad range of cell signalling functions and are targets for approximately one-third of all FDA- approved drugs. GPCRs are divided ... -
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
The genome is subjected to many forms of attack that can compromise its stability. Such forms of attack can emerge from endogenous or exogenous sources and must be counteracted by specialised repair pathways. Indeed, the ... -
Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) play critical roles in the host immune defense against intestinal parasitic helminth infections, through orchestrating the protective type 2 immune response, ...
