Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Mohapatra, SS
Wilson, ZE
Roy, S
Ley, SV
Abstract
Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf)3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing for rapid investigation of scope with straightforward work up facilitating product isolation.
Description
Keywords
alkylation, scandium triflate, bis(indolyl)methanes, flow, catalysis
Journal Title
Tetrahedron
Conference Name
Journal ISSN
0040-4020
1464-5416
1464-5416
Volume Title
73
Publisher
Elsevier
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
British Council (13)
Engineering and Physical Sciences Research Council (EP/K039520/1)
British Council (13)
Engineering and Physical Sciences Research Council (EP/K039520/1)
We gratefully acknowledge funding from the British Council, UK and DST-Inspire, India (Newton-Bhabha Ph.D Placement Programme, SSM) and the Engineering and Physical Sciences Research Council (grants EP/K009494/1 and EP/K039520/1).