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dc.contributor.authorPrince, David Cen
dc.contributor.authorRallapalli, Ghanasyamen
dc.contributor.authorXu, Deyangen
dc.contributor.authorSchoonbeek, Henk-janen
dc.contributor.authorÇevik, Volkanen
dc.contributor.authorAsai, Shutaen
dc.contributor.authorKemen, Ericen
dc.contributor.authorCruz-Mireles, Neftalyen
dc.contributor.authorKemen, Arianeen
dc.contributor.authorBelhaj, Khaoulaen
dc.contributor.authorSchornack, Sebastianen
dc.contributor.authorKamoun, Sophienen
dc.contributor.authorHolub, Eric Ben
dc.contributor.authorHalkier, Barbara Aen
dc.contributor.authorJones, Jonathan DGen
dc.date.accessioned2017-05-05T10:58:23Z
dc.date.available2017-05-05T10:58:23Z
dc.date.issued2017-03-20en
dc.identifier.citationBMC Biology. 2017 Mar 20;15(1):20
dc.identifier.issn1741-7007
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/264064
dc.description.abstractAbstract Background Plants are exposed to diverse pathogens and pests, yet most plants are resistant to most plant pathogens. Non-host resistance describes the ability of all members of a plant species to successfully prevent colonization by any given member of a pathogen species. White blister rust caused by Albugo species can overcome non-host resistance and enable secondary infection and reproduction of usually non-virulent pathogens, including the potato late blight pathogen Phytophthora infestans on Arabidopsis thaliana. However, the molecular basis of host defense suppression in this complex plant–microbe interaction is unclear. Here, we investigate specific defense mechanisms in Arabidopsis that are suppressed by Albugo infection. Results Gene expression profiling revealed that two species of Albugo upregulate genes associated with tryptophan-derived antimicrobial metabolites in Arabidopsis. Albugo laibachii-infected tissue has altered levels of these metabolites, with lower indol-3-yl methylglucosinolate and higher camalexin accumulation than uninfected tissue. We investigated the contribution of these Albugo-imposed phenotypes to suppression of non-host resistance to P. infestans. Absence of tryptophan-derived antimicrobial compounds enables P. infestans colonization of Arabidopsis, although to a lesser extent than Albugo-infected tissue. A. laibachii also suppresses a subset of genes regulated by salicylic acid; however, salicylic acid plays only a minor role in non-host resistance to P. infestans. Conclusions Albugo sp. alter tryptophan-derived metabolites and suppress elements of the responses to salicylic acid in Arabidopsis. Albugo sp. imposed alterations in tryptophan-derived metabolites may play a role in Arabidopsis non-host resistance to P. infestans. Understanding the basis of non-host resistance to pathogens such as P. infestans could assist in development of strategies to elevate food security.
dc.titleAlbugo-imposed changes to tryptophan-derived antimicrobial metabolite biosynthesis may contribute to suppression of non-host resistance to Phytophthora infestans in Arabidopsis thalianaen
dc.typeArticle
dc.date.updated2017-05-05T10:58:22Z
dc.language.rfc3066en
dc.rights.holderJones et al.
prism.publicationDate2017en
dc.identifier.doi10.17863/CAM.9425
dcterms.dateAccepted2017-02-22en
rioxxterms.versionofrecord10.1186/s12915-017-0360-zen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-03-20en
dc.contributor.orcidSchornack, Sebastian [0000-0002-7836-5881]
dc.identifier.eissn1741-7007
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idGatsby Charitable Foundation (unknown)


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