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dc.contributor.authorKehagia, Angieen
dc.contributor.authorYe, Rongen
dc.contributor.authorJoyce, DWen
dc.contributor.authorDoyle, OMen
dc.contributor.authorRowe, Jamesen
dc.contributor.authorRobbins, Trevoren
dc.date.accessioned2017-05-15T10:22:35Z
dc.date.available2017-05-15T10:22:35Z
dc.date.issued2017-08en
dc.identifier.issn0898-929X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/264226
dc.description.abstractCognitive control has traditionally been associated with pFC based on observations of deficits in patients with frontal lesions. However, evidence from patients with Parkinson's disease indicates that subcortical regions also contribute to control under certain conditions. We scanned 17 healthy volunteers while they performed a task-switching paradigm that previously dissociated performance deficits arising from frontal lesions in comparison with Parkinson's disease, as a function of the abstraction of the rules that are switched. From a multivoxel pattern analysis by Gaussian Process Classification, we then estimated the forward (generative) model to infer regional patterns of activity that predict Switch/Repeat behavior between rule conditions. At 1000 permutations, Switch/Repeat classification accuracy for concrete rules was significant in the BG, but at chance in the frontal lobe. The inverse pattern was obtained for abstract rules, whereby the conditions were successfully discriminated in the frontal lobe but not in the BG. This double dissociation highlights the difference between cortical and subcortical contributions to cognitive control and demonstrates the utility of multivariate approaches in investigations of functions that rely on distributed and overlapping neural substrates.
dc.description.sponsorshipThis research was sponsored by a Wellcome Trust grant (076274/Z/04/Z) to T. W. R., B. J. Everitt, A. C. Roberts, and B. J. Sahakian and was completed at the University of Cambridge Behavioural and Clinical Neuroscience Institute, supported by a joint award from the Medical Research Council and the Wellcome Trust, as well as a Wellcome Trust Senior Investigator Award to T. W. R. (104631/Z/14/Z) and a Senior Fellowship award to J. B. R. (103838). A. A. K. was supported by an Isaac Newton fellowship and the Wellcome Trust (077029). R. Y. is grateful for support from the China Scholarship Council (CSC). D. W. J. is an NIHR academic clinical lecturer. O. M. D. gratefully acknowledges support from the Engineering and Physical Sciences Research Council (EPSRC grant EP/L000296/1).
dc.languageengen
dc.language.isoenen
dc.publisherMassachusetts Institute of Technology Press
dc.titleParsing the Roles of the Frontal Lobes and BG in Task Control Using Multivoxel Pattern Analysisen
dc.typeArticle
prism.endingPage1401
prism.issueIdentifier8en
prism.publicationDate2017en
prism.publicationNameJournal of Cognitive Neuroscienceen
prism.startingPage1390
prism.volume29en
dc.identifier.doi10.17863/CAM.9632
dcterms.dateAccepted2017-03-11en
rioxxterms.versionofrecord10.1162/jocn_a_01130en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-08en
dc.contributor.orcidYe, Rong [0000-0003-2529-7755]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.contributor.orcidRobbins, Trevor [0000-0003-0642-5977]
dc.identifier.eissn1530-8898
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (103838/Z/14/Z)
pubs.funder-project-idWellcome Trust (076274/Z/04/Z)
pubs.funder-project-idWellcome Trust (093875/Z/10/Z)
pubs.funder-project-idMRC (G1000183)
pubs.funder-project-idWELLCOME TRUST (104631/Z/14/Z)
pubs.funder-project-idMedical Research Council (MC_U105597119)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (G0001354)
cam.issuedOnline2017-06-29en
cam.orpheus.successWed May 13 09:00:10 BST 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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