Signalling in the gut endocrine axis
Physiology and Behavior
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Gribble, F., & Reimann, F. (2017). Signalling in the gut endocrine axis. Physiology and Behavior https://doi.org/10.1016/j.physbeh.2017.02.039
Enteroendocrine cells are sensory cells located in the intestinal epithelium that produce a variety of hormonal regulators of gastrointestinal physiology, metabolism and food intake. They detect the absorption of a wide range of ingested nutrients via pathways that include transporter-mediated uptake, G-protein coupled receptors and ion channels. This review will describe mechanisms by which the L-cells that produce Glucagon Like Peptide-1 (GLP-1) respond to different components of ingested food, and the importance of these pathways not only for understanding physiology, but also for developing new treatments for type 2 diabetes and obesity.
FMG and FR are funded by grants from the Wellcome Trust and MRC.
External DOI: https://doi.org/10.1016/j.physbeh.2017.02.039
This record's URL: https://www.repository.cam.ac.uk/handle/1810/264239
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