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Signalling in the gut endocrine axis

Accepted version
Peer-reviewed

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Type

Article

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Authors

Gribble, FM 

Abstract

Enteroendocrine cells are sensory cells located in the intestinal epithelium that produce a variety of hormonal regulators of gastrointestinal physiology, metabolism and food intake. They detect the absorption of a wide range of ingested nutrients via pathways that include transporter-mediated uptake, G-protein coupled receptors and ion channels. This review will describe mechanisms by which the L-cells that produce Glucagon Like Peptide-1 (GLP-1) respond to different components of ingested food, and the importance of these pathways not only for understanding physiology, but also for developing new treatments for type 2 diabetes and obesity.

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Keywords

Animals, Enteroendocrine Cells, Gastrointestinal Hormones, Gastrointestinal Tract, Humans, Signal Transduction

Journal Title

Physiology and Behavior

Conference Name

Journal ISSN

0031-9384
1873-507X

Volume Title

Publisher

Elsevier
Sponsorship
Medical Research Council (MC_UU_12012/3)
Medical Research Council (MC_PC_12012)
FMG and FR are funded by grants from the Wellcome Trust and MRC.