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dc.contributor.authorJochmans, I
dc.contributor.authorNicholson, Michael
dc.contributor.authorHosgood, Sarah
dc.date.accessioned2017-05-17T13:33:01Z
dc.date.available2017-05-17T13:33:01Z
dc.date.issued2017-06-01
dc.identifier.issn1087-2418
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/264276
dc.description.abstractPurpose of review: Machine perfusion technologies provide an opportunity for improved preservation, organ assessment, and resuscitation of damaged kidneys. This review summarizes the recent advances in hypothermic and normothermic kidney machine perfusion technologies. Recent findings: Modifications to the perfusion conditions with the addition of oxygen during hypothermic machine perfusion can support a low level of metabolism, which in experimental settings improves graft function. Normothermic machine perfusion technologies are evolving in different directions including short-duration resuscitation, more prolonged periods of perfusion, and the transition between hypothermic and normothermic conditions. Clinical trials are ongoing in both hypothermic and normothermic settings. Functional parameters can be used to assess kidney quality and although normothermic machine perfusion may hold an advantage over hypothermic machine perfusion, new metabolomic, proteomic, and genomic technologies may be applied in the future to both technologies to provide more rigorous information on kidney quality. Promoting recovery by introducing an intervention during perfusion is an attractive area of research and therapies targeting the endothelium are a particular area of interest. Summary: A great deal of research is still needed to optimize and logistically place hypothermic and normothermic perfusion technologies. In the future, we may progress toward organ-tailored preservation whereby high-risk kidneys can undergo assessment and repair before transplantation.
dc.description.sponsorshipThe research was supported by the National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Organ Donation and Transplantation at the University of Cambridge in collaboration with Newcastle University and in partnership with NHS Blood and Transplant (NHSBT).
dc.languageeng
dc.language.isoen
dc.publisherWolters Kluwer
dc.subjectgraft resuscitation
dc.subjectgraft viability
dc.subjecthypothermic machine perfusion
dc.subjectnormothermic machine perfusion
dc.subjectoxygenated machine perfusion
dc.titleKidney perfusion: some like it hot others prefer to keep it cool.
dc.typeArticle
prism.endingPage266
prism.issueIdentifier3
prism.publicationDate2017
prism.publicationNameCurrent Opinion in Organ Transplantation
prism.startingPage260
prism.volume22
dc.identifier.doi10.17863/CAM.9692
dcterms.dateAccepted2017-02-21
rioxxterms.versionofrecord10.1097/MOT.0000000000000405
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-06-01
dc.contributor.orcidNicholson, Michael [0000-0001-7620-0664]
dc.contributor.orcidHosgood, Sarah [0000-0002-8039-143X]
dc.identifier.eissn1531-7013
rioxxterms.typeJournal Article/Review
cam.issuedOnline2017-03-16
rioxxterms.freetoread.startdate2018-03-16


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