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dc.contributor.authorPhelan, CMen
dc.contributor.authorKuchenbaecker, KBen
dc.contributor.authorTyrer, Jonathanen
dc.contributor.authorKar, SPen
dc.contributor.authorLawrenson, Ken
dc.contributor.authorWinham, SJen
dc.contributor.authorDennis, Joeen
dc.contributor.authorPirie, Aen
dc.contributor.authorRiggan, MJen
dc.contributor.authorChornokur, Gen
dc.contributor.authorEarp, MAen
dc.contributor.authorLyra, PCen
dc.contributor.authorLee, JMen
dc.contributor.authorCoetzee, Sen
dc.contributor.authorBeesley, Jen
dc.contributor.authorMcGuffog, Len
dc.contributor.authorSoucy, Pen
dc.contributor.authorDicks, Een
dc.contributor.authorLee, Andrewen
dc.contributor.authorBarrowdale, Den
dc.contributor.authorLecarpentier, Jen
dc.contributor.authorLeslie, Gen
dc.contributor.authorAalfs, CMen
dc.contributor.authorAben, KKHen
dc.contributor.authorAdams, Men
dc.contributor.authorAdlard, Jen
dc.contributor.authorAndrulis, ILen
dc.contributor.authorAnton-Culver, Hen
dc.contributor.authorAntonenkova, Nen
dc.contributor.authorAOCS study group,en
dc.contributor.authorAravantinos, Gen
dc.contributor.authorArnold, Nen
dc.contributor.authorArun, BKen
dc.contributor.authorArver, Ben
dc.contributor.authorAzzollini, Jen
dc.contributor.authorBalmaña, Jen
dc.contributor.authorBanerjee, SNen
dc.contributor.authorBarjhoux, Len
dc.contributor.authorBarkardottir, RBen
dc.contributor.authorBean, Yen
dc.contributor.authorBeckmann, MWen
dc.contributor.authorBeeghly-Fadiel, Aen
dc.contributor.authorBenitez, Jen
dc.contributor.authorBermisheva, Men
dc.contributor.authorBernardini, MQen
dc.contributor.authorBirrer, MJen
dc.contributor.authorBjorge, Len
dc.contributor.authorBlack, Aen
dc.contributor.authorBlankstein, Ken
dc.contributor.authorBlok, MJen
dc.contributor.authorBodelon, Cen
dc.contributor.authorBogdanova, Nen
dc.contributor.authorBojesen, Aen
dc.contributor.authorBonanni, Ben
dc.contributor.authorBorg, Åen
dc.contributor.authorBradbury, ARen
dc.contributor.authorBrenton, Jamesen
dc.contributor.authorBrewer, Cen
dc.contributor.authorBrinton, Len
dc.contributor.authorBroberg, Pen
dc.contributor.authorBrooks-Wilson, Aen
dc.contributor.authorBruinsma, Fen
dc.contributor.authorBrunet, Jen
dc.contributor.authorBuecher, Ben
dc.contributor.authorButzow, Ren
dc.contributor.authorBuys, SSen
dc.contributor.authorCaldes, Ten
dc.contributor.authorCaligo, MAen
dc.contributor.authorCampbell, Ien
dc.contributor.authorCannioto, Ren
dc.contributor.authorCarney, MEen
dc.contributor.authorCescon, Ten
dc.contributor.authorChan, SBen
dc.contributor.authorChang-Claude, Jen
dc.contributor.authorChanock, Sen
dc.contributor.authorChen, XQen
dc.contributor.authorChiew, Y-Een
dc.contributor.authorChiquette, Jen
dc.contributor.authorChung, WKen
dc.contributor.authorClaes, KBMen
dc.contributor.authorConner, Ten
dc.contributor.authorCook, LSen
dc.contributor.authorCook, Jen
dc.contributor.authorCramer, DWen
dc.contributor.authorCunningham, JMen
dc.contributor.authorD'Aloisio, AAen
dc.contributor.authorDaly, MBen
dc.contributor.authorDamiola, Fen
dc.contributor.authorDamirovna, SDen
dc.contributor.authorDansonka-Mieszkowska, Aen
dc.contributor.authorDao, Fen
dc.contributor.authorDavidson, Ren
dc.contributor.authorDeFazio, Aen
dc.contributor.authorDelnatte, Cen
dc.contributor.authorDoheny, KFen
dc.contributor.authorDiez, Oen
dc.contributor.authorDing, YCen
dc.contributor.authorDoherty, JAen
dc.contributor.authorDomchek, SMen
dc.contributor.authorDorfling, CMen
dc.contributor.authorDörk, Ten
dc.contributor.authorDossus, Len
dc.contributor.authorDuran, Men
dc.contributor.authorDürst, Men
dc.contributor.authorDworniczak, Ben
dc.contributor.authorEccles, Den
dc.contributor.authorEdwards, Ten
dc.contributor.authorEeles, Ren
dc.contributor.authorEilber, Uen
dc.contributor.authorEjlertsen, Ben
dc.contributor.authorEkici, ABen
dc.contributor.authorEllis, Sen
dc.contributor.authorElvira, Men
dc.contributor.authorEMBRACE Study,en
dc.contributor.authorEng, KHen
dc.contributor.authorEngel, Cen
dc.contributor.authorEvans, DGen
dc.contributor.authorFasching, PAen
dc.contributor.authorFerguson, Sen
dc.contributor.authorFerrer, SFen
dc.contributor.authorFlanagan, JMen
dc.contributor.authorFogarty, ZCen
dc.contributor.authorFortner, RTen
dc.contributor.authorFostira, Fen
dc.contributor.authorFoulkes, WDen
dc.contributor.authorFountzilas, Gen
dc.contributor.authorFridley, BLen
dc.contributor.authorFriebel, TMen
dc.contributor.authorFriedman, Een
dc.contributor.authorFrost, Den
dc.contributor.authorGanz, PAen
dc.contributor.authorGarber, Jen
dc.contributor.authorGarcía, MJen
dc.contributor.authorGarcia-Barberan, Ven
dc.contributor.authorGehrig, Aen
dc.contributor.authorGEMO Study Collaborators,en
dc.contributor.authorGentry-Maharaj, Aen
dc.contributor.authorGerdes, A-Men
dc.contributor.authorGiles, GGen
dc.contributor.authorGlasspool, Ren
dc.contributor.authorGlendon, Gen
dc.contributor.authorGodwin, AKen
dc.contributor.authorGoldgar, DEen
dc.contributor.authorGoranova, Ten
dc.contributor.authorGore, Men
dc.contributor.authorGreene, MHen
dc.contributor.authorGronwald, Jen
dc.contributor.authorGruber, Sen
dc.contributor.authorHahnen, Een
dc.contributor.authorHaiman, CAen
dc.contributor.authorHåkansson, Nen
dc.contributor.authorHamann, Uen
dc.contributor.authorHansen, TVOen
dc.contributor.authorHarrington, PAen
dc.contributor.authorHarris, HRen
dc.contributor.authorHauke, Jen
dc.contributor.authorHEBON Study,en
dc.contributor.authorHein, Aen
dc.contributor.authorHenderson, Aen
dc.contributor.authorHildebrandt, MATen
dc.contributor.authorHillemanns, Pen
dc.contributor.authorHodgson, Sen
dc.contributor.authorHøgdall, CKen
dc.contributor.authorHøgdall, Een
dc.contributor.authorHogervorst, FBLen
dc.contributor.authorHolland, Hen
dc.contributor.authorHooning, MJen
dc.contributor.authorHosking, Ken
dc.contributor.authorHuang, R-Yen
dc.contributor.authorHulick, PJen
dc.contributor.authorHung, Jen
dc.contributor.authorHunter, DJen
dc.contributor.authorHuntsman, DGen
dc.contributor.authorHuzarski, Ten
dc.contributor.authorImyanitov, ENen
dc.contributor.authorIsaacs, Cen
dc.contributor.authorIversen, ESen
dc.contributor.authorIzatt, Len
dc.contributor.authorIzquierdo, Aen
dc.contributor.authorJakubowska, Aen
dc.contributor.authorJames, Pen
dc.contributor.authorJanavicius, Ren
dc.contributor.authorJernetz, Men
dc.contributor.authorJensen, Aen
dc.contributor.authorJensen, UBen
dc.contributor.authorJohn, EMen
dc.contributor.authorJohnatty, Sen
dc.contributor.authorJones, MEen
dc.contributor.authorKannisto, Pen
dc.contributor.authorKarlan, BYen
dc.contributor.authorKarnezis, Aen
dc.contributor.authorKast, Ken
dc.contributor.authorKConFab Investigators,en
dc.contributor.authorKennedy, CJen
dc.contributor.authorKhusnutdinova, Een
dc.contributor.authorKiemeney, LAen
dc.contributor.authorKiiski, JIen
dc.contributor.authorKim, S-Wen
dc.contributor.authorKjaer, SKen
dc.contributor.authorKöbel, Men
dc.contributor.authorKopperud, RKen
dc.contributor.authorKruse, TAen
dc.contributor.authorKupryjanczyk, Jen
dc.contributor.authorKwong, Aen
dc.contributor.authorLaitman, Yen
dc.contributor.authorLambrechts, Den
dc.contributor.authorLarrañaga, Nen
dc.contributor.authorLarson, MCen
dc.contributor.authorLazaro, Cen
dc.contributor.authorLe, NDen
dc.contributor.authorLe Marchand, Len
dc.contributor.authorLee, JWen
dc.contributor.authorLele, SBen
dc.contributor.authorLeminen, Aen
dc.contributor.authorLeroux, Den
dc.contributor.authorLester, Jen
dc.contributor.authorLesueur, Fen
dc.contributor.authorLevine, DAen
dc.contributor.authorLiang, Den
dc.contributor.authorLiebrich, Cen
dc.contributor.authorLilyquist, Jen
dc.contributor.authorLipworth, Len
dc.contributor.authorLissowska, Jen
dc.contributor.authorLu, KHen
dc.contributor.authorLubinński, Jen
dc.contributor.authorLuccarini, Cen
dc.contributor.authorLundvall, Len
dc.contributor.authorMai, PLen
dc.contributor.authorMendoza-Fandiño, Gen
dc.contributor.authorManoukian, Sen
dc.contributor.authorMassuger, LFAGen
dc.contributor.authorMay, Ten
dc.contributor.authorMazoyer, Sen
dc.contributor.authorMcAlpine, JNen
dc.contributor.authorMcGuire, Ven
dc.contributor.authorMcLaughlin, JRen
dc.contributor.authorMcNeish, Ien
dc.contributor.authorMeijers-Heijboer, Hen
dc.contributor.authorMeindl, Aen
dc.contributor.authorMenon, Uen
dc.contributor.authorMensenkamp, ARen
dc.contributor.authorMerritt, MAen
dc.contributor.authorMilne, RLen
dc.contributor.authorMitchell, Gen
dc.contributor.authorModugno, Fen
dc.contributor.authorMoes-Sosnowska, Jen
dc.contributor.authorMoffitt, Men
dc.contributor.authorMontagna, Men
dc.contributor.authorMoysich, KBen
dc.contributor.authorMulligan, AMen
dc.contributor.authorMusinsky, Jen
dc.contributor.authorNathanson, KLen
dc.contributor.authorNedergaard, Len
dc.contributor.authorNess, RBen
dc.contributor.authorNeuhausen, SLen
dc.contributor.authorNevanlinna, Hen
dc.contributor.authorNiederacher, Den
dc.contributor.authorNussbaum, RLen
dc.contributor.authorOdunsi, Ken
dc.contributor.authorOlah, Een
dc.contributor.authorOlopade, OIen
dc.contributor.authorOlsson, Hen
dc.contributor.authorOlswold, Cen
dc.contributor.authorO'Malley, DMen
dc.contributor.authorOng, K-Ren
dc.contributor.authorOnland-Moret, NCen
dc.contributor.authorOPAL study group,en
dc.contributor.authorOrr, Nen
dc.contributor.authorOrsulic, Sen
dc.contributor.authorOsorio, Aen
dc.contributor.authorPalli, Den
dc.contributor.authorPapi, Len
dc.contributor.authorPark-Simon, T-Wen
dc.contributor.authorPaul, Jen
dc.contributor.authorPearce, CLen
dc.contributor.authorPedersen, ISen
dc.contributor.authorPeeters, PHMen
dc.contributor.authorPeissel, Ben
dc.contributor.authorPeixoto, Aen
dc.contributor.authorPejovic, Ten
dc.contributor.authorPelttari, LMen
dc.contributor.authorPermuth, JBen
dc.contributor.authorPeterlongo, Pen
dc.contributor.authorPezzani, Len
dc.contributor.authorPfeiler, Gen
dc.contributor.authorPhillips, K-Aen
dc.contributor.authorPiedmonte, Men
dc.contributor.authorPike, MCen
dc.contributor.authorPiskorz, AMen
dc.contributor.authorPoblete, SRen
dc.contributor.authorPocza, Ten
dc.contributor.authorPoole, EMen
dc.contributor.authorPoppe, Ben
dc.contributor.authorPorteous, MEen
dc.contributor.authorPrieur, Fen
dc.contributor.authorProkofyeva, Den
dc.contributor.authorPugh, Een
dc.contributor.authorPujana, MAen
dc.contributor.authorPujol, Pen
dc.contributor.authorRadice, Pen
dc.contributor.authorRantala, Jen
dc.contributor.authorRappaport-Fuerhauser, Cen
dc.contributor.authorRennert, Gen
dc.contributor.authorRhiem, Ken
dc.contributor.authorRice, Pen
dc.contributor.authorRichardson, Aen
dc.contributor.authorRobson, Men
dc.contributor.authorRodriguez, GCen
dc.contributor.authorRodríguez-Antona, Cen
dc.contributor.authorRomm, Jen
dc.contributor.authorRookus, MAen
dc.contributor.authorRossing, MAen
dc.contributor.authorRothstein, JHen
dc.contributor.authorRudolph, Aen
dc.contributor.authorRunnebaum, IBen
dc.contributor.authorSalvesen, HBen
dc.contributor.authorSandler, DPen
dc.contributor.authorSchoemaker, MJen
dc.contributor.authorSenter, Len
dc.contributor.authorSetiawan, VWen
dc.contributor.authorSeveri, Gen
dc.contributor.authorSharma, Pen
dc.contributor.authorShelford, Ten
dc.contributor.authorSiddiqui, Nen
dc.contributor.authorSide, LEen
dc.contributor.authorSieh, Wen
dc.contributor.authorSinger, CFen
dc.contributor.authorSobol, Hen
dc.contributor.authorSong, Honglinen
dc.contributor.authorSouthey, MCen
dc.contributor.authorSpurdle, ABen
dc.contributor.authorStadler, Zen
dc.contributor.authorSteinemann, Den
dc.contributor.authorStoppa-Lyonnet, Den
dc.contributor.authorSucheston-Campbell, LEen
dc.contributor.authorSukiennicki, Gen
dc.contributor.authorSutphen, Ren
dc.contributor.authorSutter, Cen
dc.contributor.authorSwerdlow, AJen
dc.contributor.authorSzabo, CIen
dc.contributor.authorSzafron, Len
dc.contributor.authorTan, YYen
dc.contributor.authorTaylor, JAen
dc.contributor.authorTea, M-Ken
dc.contributor.authorTeixeira, MRen
dc.contributor.authorTeo, S-Hen
dc.contributor.authorTerry, KLen
dc.contributor.authorThompson, PJen
dc.contributor.authorThomsen, LCVen
dc.contributor.authorThull, DLen
dc.contributor.authorTihomirova, Len
dc.contributor.authorTinker, AVen
dc.contributor.authorTischkowitz, Marcen
dc.contributor.authorTognazzo, Sen
dc.contributor.authorToland, AEen
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dc.contributor.authorTrabert, Ben
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dc.contributor.authorTrichopoulou, Aen
dc.contributor.authorTung, Nen
dc.contributor.authorTworoger, SSen
dc.contributor.authorvan Altena, AMen
dc.contributor.authorVan Den Berg, Den
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dc.contributor.authorvan der Luijt, RBen
dc.contributor.authorVan Heetvelde, Men
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dc.contributor.authorvan Rensburg, EJen
dc.contributor.authorVanderstichele, Aen
dc.contributor.authorVaron-Mateeva, Ren
dc.contributor.authorVega, Aen
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dc.contributor.authorVierkant, RAen
dc.contributor.authorVijai, Jen
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dc.contributor.authorWalker, Len
dc.contributor.authorWalsh, Cen
dc.contributor.authorWand, Den
dc.contributor.authorWang-Gohrke, Sen
dc.contributor.authorWappenschmidt, Ben
dc.contributor.authorWebb, PMen
dc.contributor.authorWeinberg, CRen
dc.contributor.authorWeitzel, JNen
dc.contributor.authorWentzensen, Nen
dc.contributor.authorWhittemore, ASen
dc.contributor.authorWijnen, JTen
dc.contributor.authorWilkens, LRen
dc.contributor.authorWolk, Aen
dc.contributor.authorWoo, Men
dc.contributor.authorWu, Xen
dc.contributor.authorWu, AHen
dc.contributor.authorYang, Hen
dc.contributor.authorYannoukakos, Den
dc.contributor.authorZiogas, Aen
dc.contributor.authorZorn, KKen
dc.contributor.authorNarod, SAen
dc.contributor.authorEaston, Douglasen
dc.contributor.authorAmos, CIen
dc.contributor.authorSchildkraut, JMen
dc.contributor.authorRamus, SJen
dc.contributor.authorOttini, Len
dc.contributor.authorGoodman, MTen
dc.contributor.authorPark, SKen
dc.contributor.authorKelemen, LEen
dc.contributor.authorRisch, HAen
dc.contributor.authorThomassen, Men
dc.contributor.authorOffit, Ken
dc.contributor.authorSimard, Jen
dc.contributor.authorSchmutzler, RKen
dc.contributor.authorHazelett, Den
dc.contributor.authorMonteiro, ANen
dc.contributor.authorCouch, FJen
dc.contributor.authorBerchuck, Aen
dc.contributor.authorChenevix-Trench, Gen
dc.contributor.authorGoode, ELen
dc.contributor.authorSellers, TAen
dc.contributor.authorGayther, SAen
dc.contributor.authorAntoniou, Antonisen
dc.contributor.authorPharoah, Paulen
dc.date.accessioned2017-05-23T14:47:45Z
dc.date.available2017-05-23T14:47:45Z
dc.identifier.issn1061-4036
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/264367
dc.description.abstractTo identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 $\textit{BRCA1}$ and $\textit{BRCA2}$ mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
dc.description.sponsorshipThe OCAC OncoArray genotyping project was funded through grants from the US National Institutes of Health (CA1X01HG007491-01 (C.I.A.), U19-CA148112 (T.A.S.), R01-CA149429 (C.M.P.) and R01-CA058598 (M.T.G.)); Canadian Institutes of Health Research (MOP-86727 (L.E.K.)); and the Ovarian Cancer Research Fund (A.B.). Funding for the CIMBA OncoArray genotyping was provided by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the Ministère de l'Économie, de la Science et de l'Innovation du Québec through Génome Québec, the Quebec Breast Cancer Foundation for the PERSPECTIVE project, the US National Institutes of Health (CA1X01HG007491-01 (C.I.A.)), the Odense University Hospital Research Foundation (M.T.), the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (1420190 (S.K.P.)), the Italian Association for Cancer Research (IG16933 (L.O.)) and German Cancer Aid (110837 (R.K.S.). Funding sources for the contributing studies are provided in the Supplementary Note.
dc.languageengen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.subjectepidemiologyen
dc.subjectgenome-wide association studiesen
dc.subjectovarian canceren
dc.titleIdentification of 12 new susceptibility loci for different histotypes of epithelial ovarian canceren
dc.typeArticle
prism.endingPage691
prism.issueIdentifier5en
prism.publicationNameNature Geneticsen
prism.startingPage680
prism.volume49en
dc.identifier.doi10.17863/CAM.9859
dcterms.dateAccepted2017-03-03en
rioxxterms.versionofrecord10.1038/ng.3826en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-03-03en
dc.contributor.orcidTyrer, Jonathan [0000-0003-3724-4757]
dc.contributor.orcidDennis, Joe [0000-0003-4591-1214]
dc.contributor.orcidLee, Andrew [0000-0003-0677-0252]
dc.contributor.orcidBrenton, James [0000-0002-5738-6683]
dc.contributor.orcidSong, Honglin [0000-0001-5076-7371]
dc.contributor.orcidTischkowitz, Marc [0000-0002-7880-0628]
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.contributor.orcidAntoniou, Antonis [0000-0001-9223-3116]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.identifier.eissn1546-1718
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (10124)
pubs.funder-project-idCancer Research UK (16561)
cam.issuedOnline2017-03-27en
rioxxterms.freetoread.startdate2018-03-27


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