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Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial


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Authors

Markey, O 
Vasilopoulou, D 
Kliem, KE 
Fagan, CC 

Abstract

Background: Dairy products are a major contributor to dietary SFA. Partial replacement of milk SFA with unsaturated fatty acids (FAs) is possible through oleic-acid rich supplementation of the dairy cow diet. To assess adherence to the intervention of SFA-reduced, MUFA-enriched dairy product consumption in the RESET (REplacement of SaturatEd fat in dairy on Total cholesterol) study using 4-d weighed dietary records, in addition to plasma phospholipid FA (PL-FA) status. Methods: In a randomised, controlled, crossover design, free-living UK participants identified as moderate risk for CVD (n = 54) were required to replace habitually consumed dairy foods (milk, cheese and butter), with study products with a FA profile typical of retail products (control) or SFA-reduced, MUFA-enriched profile (modified), for two 12-week periods, separated by an 8-week washout period. A flexible food-exchange model was used to implement each isoenergetic high-fat, high-dairy diet (38% of total energy intake (%TE) total fat): control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA). Results: Following the modified diet, there was a smaller increase in SFA (17.2%TE vs. 19.1%TE; p < 0.001) and greater increase in MUFA intake (15.4%TE vs. 11.8%TE; p < 0.0001) when compared with the control. PL-FA analysis revealed lower total SFAs (p = 0.006), higher total cis-MUFAs and trans-MUFAs (both p < 0.0001) following the modified diet. Conclusion: The food-exchange model was successfully used to achieve RESET dietary targets by partial replacement of SFAs with MUFAs in dairy products, a finding reflected in the PL-FA profile and indicative of objective dietary compliance. Trial registration: ClinicalTrials.gov Identifier: NCT02089035 , date 05-01-2014.

Description

Keywords

cardiovascular disease, dairy products, dietary fat composition, fatty acids, food-exchange model, monounsaturated fatty acids, nutrition assessment, phospholipids, saturated fatty acids

Journal Title

Nutrition Journal

Conference Name

Journal ISSN

1475-2891
1475-2891

Volume Title

16

Publisher

BioMed Central
Sponsorship
MRC (TT/5107)
BBSRC (BB/P028195/1)
BBSRC (BB/M027252/2)
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Biotechnology and Biological Sciences Research Council (BB/M027252/1)
This work was supported by funding from the Medical Research Council (United Kingdom; Ref: MR/K020218/1).