Demystifying blood stem cell fates

Hamey, Fiona; Gottgens, Berthold

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Authors

Hamey, Fiona

Gottgens, Berthold

Publication Date

2017-03-31

Journal Title

Nature Cell Biology

ISSN

1465-7392

Publisher

Nature Publishing Group

Volume

Issue

Pages

261-263

Language

English

Type

Article

This Version

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Citation

Hamey, F., & Gottgens, B. (2017). Demystifying blood stem cell fates. Nature Cell Biology, 19 (4), 261-263. https://doi.org/10.1038/ncb3494

Abstract

Determining the differentiation potential of stem and progenitor cells is essential for understanding their function, yet our ability to do so is limited by the restrictions of experimental assays. Based on single-cell functional and molecular profiling experiments, a new computational approach shows how lineage commitment may occur in human haematopoiesis.

Keywords

cell lineage, haematopoietic stem cells, stem-cell differentiation

Sponsorship

Cancer Research UK (21762)

MRC (MR/K500975/1)

Leukaemia & Lymphoma Research (12029)

MRC (MC_PC_12009)

MEDICAL RESEARCH COUNCIL (MR/M008975/1)

Identifiers

External DOI: https://doi.org/10.1038/ncb3494

This record's URL: https://www.repository.cam.ac.uk/handle/1810/264438

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