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dc.contributor.authorHarrison, Seamus Conoren
dc.contributor.authorLennon, Ren
dc.contributor.authorHolly, Jen
dc.contributor.authorHiggins, JPTen
dc.contributor.authorGardner, Men
dc.contributor.authorPerks, Cen
dc.contributor.authorGaunt, Ten
dc.contributor.authorTan, Ven
dc.contributor.authorBorwick, Cen
dc.contributor.authorEmmet, Pen
dc.contributor.authorJeffreys, Men
dc.contributor.authorNorthstone, Ken
dc.contributor.authorRinaldi, Sen
dc.contributor.authorThomas, Sen
dc.contributor.authorTurner, Suzanneen
dc.contributor.authorPease, Aen
dc.contributor.authorVilenchick, Ven
dc.contributor.authorMartin, RMen
dc.contributor.authorLewis, SJen
dc.date.accessioned2017-05-29T09:09:09Z
dc.date.available2017-05-29T09:09:09Z
dc.date.issued2017-06-01en
dc.identifier.issn0957-5243
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/264476
dc.description.abstract$\textbf{PURPOSE}$: To establish whether the association between milk intake and prostate cancer operates via the insulin-like growth factor (IGF) pathway (including IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3). $\textbf{METHODS}$: Systematic review, collating data from all relevant studies examining associations of milk with IGF, and those examining associations of IGF with prostate cancer risk and progression. Data were extracted from experimental and observational studies conducted in either humans or animals, and analyzed using meta-analysis where possible, with summary data presented otherwise. $\textbf{RESULTS}$: One hundred and seventy-two studies met the inclusion criteria: 31 examining the milk-IGF relationship; 132 examining the IGF-prostate cancer relationship in humans; and 10 animal studies examining the IGF-prostate cancer relationship. There was moderate evidence that circulating IGF-I and IGFBP-3 increase with milk (and dairy protein) intake (an estimated standardized effect size of 0.10 SD increase in IGF-I and 0.05 SD in IGFBP-3 per 1 SD increase in milk intake). There was moderate evidence that prostate cancer risk increased with IGF-I (Random effects meta-analysis OR per SD increase in IGF-I 1.09; 95% CI 1.03, 1.16; n = 51 studies) and decreased with IGFBP-3 (OR 0.90; 0.83, 0.98; n = 39 studies), but not with other growth factors. The IGFBP-3 -202A/C single nucleotide polymorphism was positively associated with prostate cancer (pooled OR for A/C vs. AA = 1.22; 95% CI 0.84, 1.79; OR for C/C vs. AA = 1.51; 1.03, 2.21, n = 8 studies). No strong associations were observed for IGF-II, IGFBP-1 or IGFBP-2 with either milk intake or prostate cancer risk. There was little consistency within the data extracted from the small number of animal studies. There was additional evidence to suggest that the suppression of IGF-II can reduce tumor size, and contradictory evidence with regards to the effect of IGFBP-3 suppression on tumor progression. $\textbf{CONCLUSION}$: IGF-I is a potential mechanism underlying the observed associations between milk intake and prostate cancer risk.
dc.description.sponsorshipFunded by World Cancer Research Fund (grant number: RFA 2012/620). SH is a Wellcome Trust Funded PhD student with Grant code 102432/Z/13/Z. Additionally supported by funding from the MRC Integrative Epidemiology Unit at the University of Bristol (MC_UU_12013/1, MC_UU_12013/2) and a Cancer Research UK (C18281/A19169) Programme Grant (the Integrative Cancer Epidemiology Programme). RMM is supported by the National Institute for Health Research (NIHR) Bristol Nutritional Biomedical Research Unit based at University Hospitals Bristol NHS Foundation Trust and the University of Bristol.
dc.languageengen
dc.language.isoenen
dc.publisherSpringer
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectinsulin-like growth factorsen
dc.subjectmechanistic pathwayen
dc.subjectmeta-analysisen
dc.subjectmilken
dc.subjectprostate canceren
dc.subjectsystematic reviewen
dc.titleDoes milk intake promote prostate cancer initiation or progression via effects on insulin-like growth factors (IGFs)? A systematic review and meta-analysisen
dc.typeArticle
prism.endingPage528
prism.issueIdentifier6en
prism.publicationDate2017en
prism.publicationNameCancer Causes & Controlen
prism.startingPage497
prism.volume28en
dc.identifier.doi10.17863/CAM.9974
dcterms.dateAccepted2017-03-10en
rioxxterms.versionofrecord10.1007/s10552-017-0883-1en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-06-01en
dc.contributor.orcidHarrison, Seamus Conor [0000-0003-1480-1143]
dc.contributor.orcidTurner, Suzanne [0000-0002-8439-4507]
dc.identifier.eissn1573-7225
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2017-03-30en
cam.orpheus.successThu Jan 30 12:53:45 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International