Association between serum C-reactive protein and DSM-IV generalized anxiety disorder in adolescence: Findings from the ALSPAC cohort.
Publication Date
2016-10Journal Title
Neurobiology of Stress
ISSN
2352-2895
Publisher
Elsevier
Volume
4
Pages
55-61
Language
English
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Khandaker, G., Zammit, S., Lewis, G., & Jones, P. (2016). Association between serum C-reactive protein and DSM-IV generalized anxiety disorder in adolescence: Findings from the ALSPAC cohort.. Neurobiology of Stress, 4 55-61. https://doi.org/10.1016/j.ynstr.2016.02.003
Abstract
$\textit{$Background:}$ Animal studies suggest a role of inflammation in the pathophysiology of anxiety, but human studies of inflammatory markers and anxiety disorders are scarce. We report a study of serum C-reactive protein (CRP) and generalised anxiety disorder (GAD) from the general population-based ALSPAC birth cohort.
$\textit{Methods:}$ DSM-IV diagnosis of GAD was obtained from 5365 cohort members during face-to-face clinical assessment at age 16 years, of which 3392 also provided data on serum high sensitivity CRP levels. Logistic regression calculated odds ratio (OR) for GAD among individuals in top and middle thirds of CRP distribution compared with the bottom third. Effect of comorbid depression was assessed. Age, sex, body mass, ethnicity, social class, maternal education, maternal age at delivery, and family history of inflammatory conditions were included as potential confounders.
$\textit{Results:}$ Forty participants met DSM-IV criteria for GAD (0.74%). CRP levels were higher in GAD cases compared with the rest of the cohort (P = 0.005). After adjusting for potential confounders, participants in the top third of CRP values compared with the bottom third were more likely to have GAD; adjusted OR 5.06 (95% CI, 1.31-19.59). The association between CRP and GAD was consistent with a linear dose-response relationship. The pattern of association between CRP and GAD remained unchanged after excluding cases with co-morbid depression.
$\textit{Conclusions:}$ The findings are consistent with a role of inflammation in anxiety disorders. Longitudinal studies of inflammatory markers, subsequent anxiety taking into account current and past psychological stress are required to understand this association further.
Keywords
biological markers, birth cohort study, C-reactive protein, generalized anxiety disorder, systemic inflammation
Sponsorship
Dr Khandaker is supported by a Clinical Lecturer Starter Grant from the UK Academy of Medical Sciences (Grant no. 80354) and a Gosling Fellowship from the Royal College of Psychiatrists. Prof Jones acknowledges grant support from the Wellcome Trust (095844/Z/11/Z & 088869/Z/09/Z) and NIHR (RP-PG-0606-1335). The UK Medical Research Council (Grant ref: 74882), the Wellcome Trust (Grant ref: 092731) and the University of Bristol provide core support for ALSPAC. The funding bodies had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.
Funder references
CAMBS & PETERBOROUGH NHS FOUND TRUST (FB NHS/NIHR) (RP-PG-0606-1335)
Academy of Medical Sciences (unknown)
Wellcome Trust (088869/Z/09/Z)
Wellcome Trust (095844/Z/11/Z)
Wellcome Trust (094790/Z/10/Z)
Wellcome Trust (093875/Z/10/Z)
Embargo Lift Date
2100-01-01
Identifiers
External DOI: https://doi.org/10.1016/j.ynstr.2016.02.003
This record's URL: https://www.repository.cam.ac.uk/handle/1810/264707
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International, Attribution-NonCommercial-NoDerivatives 4.0 International, Attribution-NonCommercial-NoDerivatives 4.0 International