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dc.contributor.authorShah, Aartien
dc.contributor.authorBennett, Martinen
dc.date.accessioned2017-06-15T09:16:41Z
dc.date.available2017-06-15T09:16:41Z
dc.date.issued2017-03-25en
dc.identifier.issn0014-2999
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/264776
dc.description.abstractA decline in the function of the macro- and micro-vasculature occurs with ageing. DNA damage also accumulates with ageing, and thus DNA damage and repair have important roles in physiological ageing. Considerable evidence also supports a crucial role for DNA damage in the development and progression of macrovascular disease such as atherosclerosis. These findings support the concept that prolonged exposure to risk factors is a major stimulus for DNA damage within the vasculature, in part via the generation of reactive oxygen species. Genomic instability can directly affect vascular cellular function, leading to cell cycle arrest, apoptosis and premature vascular cell senescence. In contrast, the study of age-related impaired function and DNA damage mechanisms in the microvasculature is limited, although ageing is associated with microvessel endothelial dysfunction. This review examines current knowledge on the role of DNA damage and DNA repair systems in macrovascular disease such as atherosclerosis and microvascular disease. We also discuss the cellular responses to DNA damage to identify possible strategies for prevention and treatment.
dc.description.sponsorshipThis work was supported by the British Heart Foundation (grant number RG/13/14/30314) and the National Institute for Health Research Cambridge Biomedical Research Centre.
dc.languageengen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectageingen
dc.subjectatherosclerosisen
dc.subjectDNA damageen
dc.subjectendothelial cellsen
dc.subjectmicrovasculatureen
dc.titleDNA damage-dependent mechanisms of ageing and disease in the macro- and microvasculatureen
dc.typeArticle
prism.publicationDate2017en
prism.publicationNameEuropean Journal of Pharmacologyen
dc.identifier.doi10.17863/CAM.10469
dcterms.dateAccepted2017-03-23en
rioxxterms.versionofrecord10.1016/j.ejphar.2017.03.050en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2017-03-25en
dc.contributor.orcidBennett, Martin [0000-0002-2565-1825]
dc.identifier.eissn1879-0712
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Heart Foundation (PG/16/63/32307)
pubs.funder-project-idBritish Heart Foundation (PG/16/11/32021)
pubs.funder-project-idBritish Heart Foundation (PG/11/57/29003)
pubs.funder-project-idBritish Heart Foundation (RG/13/14/30314)
pubs.funder-project-idBritish Heart Foundation (PG/13/25/30014)
cam.issuedOnline2017-03-25en
rioxxterms.freetoread.startdate2018-03-25


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International