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dc.contributor.authorMcKeith, IGen
dc.contributor.authorBoeve, BFen
dc.contributor.authorDickson, DWen
dc.contributor.authorHalliday, Gen
dc.contributor.authorTaylor, J-Pen
dc.contributor.authorWeintraub, Den
dc.contributor.authorAarsland, Den
dc.contributor.authorGalvin, Jen
dc.contributor.authorAttems, Jen
dc.contributor.authorBallard, CGen
dc.contributor.authorBayston, Aen
dc.contributor.authorBeach, TGen
dc.contributor.authorBlanc, Fen
dc.contributor.authorBohnen, Nen
dc.contributor.authorBonanni, Len
dc.contributor.authorBras, Jen
dc.contributor.authorBrundin, Pen
dc.contributor.authorBurn, Den
dc.contributor.authorChen-Plotkin, Aen
dc.contributor.authorDuda, JEen
dc.contributor.authorEl-Agnaf, Oen
dc.contributor.authorFeldman, Hen
dc.contributor.authorFerman, TJen
dc.contributor.authorFfytche, Den
dc.contributor.authorFujishiro, Hen
dc.contributor.authorGalasko, Den
dc.contributor.authorGoldman, JGen
dc.contributor.authorGomperts, SNen
dc.contributor.authorGraff-Radford, NRen
dc.contributor.authorHonig, LSen
dc.contributor.authorIranzo, Aen
dc.contributor.authorKantarci, Ken
dc.contributor.authorKaufer, Den
dc.contributor.authorKukull, Wen
dc.contributor.authorLee, VMYen
dc.contributor.authorLeverenz, JBen
dc.contributor.authorLewis, Sen
dc.contributor.authorLippa, Cen
dc.contributor.authorLunde, Aen
dc.contributor.authorMasellis, Men
dc.contributor.authorMasliah, Een
dc.contributor.authorMcLean, Pen
dc.contributor.authorMollenhauer, Ben
dc.contributor.authorMontine, TJen
dc.contributor.authorMoreno, Een
dc.contributor.authorMori, Een
dc.contributor.authorMurray, Men
dc.contributor.authorO'Brien, Johnen
dc.contributor.authorOrimo, Sen
dc.contributor.authorPostuma, RBen
dc.contributor.authorRamaswamy, Sen
dc.contributor.authorRoss, OAen
dc.contributor.authorSalmon, DPen
dc.contributor.authorSingleton, Aen
dc.contributor.authorTaylor, Aen
dc.contributor.authorThomas, Aen
dc.contributor.authorTiraboschi, Pen
dc.contributor.authorToledo, JBen
dc.contributor.authorTrojanowski, JQen
dc.contributor.authorTsuang, Den
dc.contributor.authorWalker, Zen
dc.contributor.authorYamada, Men
dc.contributor.authorKosaka, Ken
dc.description.abstractThe Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade. The revised DLB consensus criteria now distinguish clearly between clinical features and diagnostic biomarkers, and give guidance about optimal methods to establish and interpret these. Substantial new information has been incorporated about previously reported aspects of DLB, with increased diagnostic weighting given to REM sleep behavior disorder and $^{123}$iodine-metaiodobenzylguanidine (MIBG) myocardial scintigraphy. The diagnostic role of other neuroimaging, electrophysiologic, and laboratory investigations is also described. Minor modifications to pathologic methods and criteria are recommended to take account of Alzheimer disease neuropathologic change, to add previously omitted Lewy-related pathology categories, and to include assessments for substantia nigra neuronal loss. Recommendations about clinical management are largely based upon expert opinion since randomized controlled trials in DLB are few. Substantial progress has been made since the previous report in the detection and recognition of DLB as a common and important clinical disorder. During that period it has been incorporated into DSM-5, as major neurocognitive disorder with Lewy bodies. There remains a pressing need to understand the underlying neurobiology and pathophysiology of DLB, to develop and deliver clinical trials with both symptomatic and disease-modifying agents, and to help patients and carers worldwide to inform themselves about the disease, its prognosis, best available treatments, ongoing research, and how to get adequate support.
dc.description.sponsorshipThe DLB Consortium meeting was organized by the Mayo School of Continuous Professional Development (MSCPD) and supported by Acadia Pharmaceuticals, Alzheimer’s Association, Axovant Sciences, Banner Health, GE Healthcare, the Lewy Body Dementia Association, the Lewy Body Society, Lundbeck, the National Institute on Aging, the National Institute on Neurologic Disease and Stroke, and an NIH grant (R13 NS095618). Kathy Fuqua, Julie Reed, and colleagues at the MSCPD provided administrative support to the consortium meeting in Fort Lauderdale. I.G.M., D.B., J.-P.T., J.A., and A.T. receive support from the UK NIHR Biomedical Research Centre awarded to the Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. Travel grant support was provided by the Alzheimer’s Research UK ARUK NE Network Centre. B.F.B., D.W.D., K.K., and T.J.F. are supported by the NIH (P50-AG016574) and the Mangurian Foundation for Lewy Body Research. G.H. is a senior principal research fellowship holder from the National Health and Medical Research Council of Australia (1079679). D.A. is a Royal Society Wolfson Research Merit Award Holder and thanks the Wolfson Foundation and the Royal Society for their support. C.G.B. thanks the Maudsley BRC for Mental Health and BRU dementia for supporting his involvement in the work. A.C.-P. receives research support from the NIH (RO1 NS082265, UO1 NS082134, P50 NS053488), the Burroughs Wellcome Fund, the Alzheimer’s Association/Michael J. Fox Foundation/Weston Biomarkers Across Neurodegenerative Disease initiative, and the Pechenik Montague Award Fund. D.f. acknowledges support from NIHR Programme Grants for Applied Research (RP-PG-0610-10100 SHAPED). O.E.-A. acknowledges support for OE laboratory from the Michael J. Fox Foundation for Parkinson’s Research (New York). S.N.G. receives support from R21 NS 090243 and the National Parkinson’s Foundation. O.A.R. is supported through the Mayo Clinic: A Morris K. Udall Parkinson’s Disease Research Center of Excellence (NINDS P50 NS072187), NINDS R01 NS078086, the Michael J. Fox Foundation for Parkinson’s Research, the Mayo Clinic AD and Related Dementias Genetics Program, and The Little Family Foundation. A.S.’s work is supported by the Intramural Research Program of the National Institute on Aging, Department of Health and Human Services. D.T. acknowledges the work of Cyrus Zabetian, MD, and Ignacio Mata, PhD, from VA Puget Sound Health Care System. J.Q.T. and V.M.Y.L.’s contributions were supported in part by a P50 NS053488 Morris K. Udall Parkinson’s Disease Research Center of Excellence grant from NINDS. P.T. acknowledges support from the Italian Ministry of Health “Ricerca Corrente.” M.Y. acknowledges support from the Japan Foundation for Neuroscience and Mental Health.
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.titleDiagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortiumen
dc.contributor.orcidO'Brien, John [0000-0002-0837-5080]
rioxxterms.typeJournal Article/Reviewen
cam.orpheus.successThu Jan 30 12:53:51 GMT 2020 - The item has an open VoR version.*

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