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dc.contributor.authorNeerincx, A
dc.contributor.authorBoyle, LH
dc.date.accessioned2017-06-27T11:22:58Z
dc.date.available2017-06-27T11:22:58Z
dc.date.issued2017-06
dc.identifier.issn0952-7915
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/265016
dc.description.abstractThe presentation of antigenic peptides by MHC class I molecules plays a vital role in generating T cell responses against infection and cancer. Over the last two decades the central role of tapasin as a peptide editor that influences the loading and optimisation of peptides onto MHC class I molecules has been extensively characterised. Recently, it has become evident that the tapasin-related protein, TAPBPR, functions as a second peptide editor which influences the peptides displayed by MHC class I molecules. Here, we review the discovery of TAPBPR and current understanding of this novel protein in relation to its closest homologue tapasin.
dc.description.sponsorshipThis work was funded by a Wellcome Trust Senior Research Fellowship 104647/Z/14/Z.
dc.languageeng
dc.language.isoen
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleProperties of the tapasin homologue TAPBPR
dc.typeArticle
prism.endingPage102
prism.publicationDate2017
prism.publicationNameCurrent Opinion in Immunology
prism.startingPage97
prism.volume46
dc.identifier.doi10.17863/CAM.10854
dcterms.dateAccepted2017-04-17
rioxxterms.versionofrecord10.1016/j.coi.2017.04.008
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.licenseref.startdate2017-06
dc.contributor.orcidBoyle, Louise [0000-0002-3105-6555]
dc.identifier.eissn1879-0372
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (085038/Z/08/Z)
pubs.funder-project-idWellcome Trust (104647/Z/14/Z)
cam.issuedOnline2017-05-18
rioxxterms.freetoread.startdate2018-05-18


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International