The U2AF1$^{S34F}$ mutation induces lineage-specific splicing alterations in myelodysplastic syndromes
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Abstract
Mutations of the splicing factor-encoding gene U2AF1 are frequent in the myelodysplastic syndromes (MDS), a myeloid malignancy, and other cancers. Patients with MDS suffer from peripheral blood cytopenias, including anemia, and an increasing percentage of bone marrow myeloblasts. We studied the impact of the common U2AF1
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1558-8238