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dc.contributor.authorParker, Aen
dc.contributor.authorKaufman, Jimen
dc.date.accessioned2017-06-29T09:28:09Z
dc.date.available2017-06-29T09:28:09Z
dc.date.issued2017-06-01en
dc.identifier.issn0952-7915
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/265076
dc.description.abstractAlmost all knowledge about the structure and function of MHC class II molecules outside of mammals comes from work with chickens. Most of the genes implicated in the class II system are present in chickens, so it is likely that the machinery of antigen processing and peptide-loading is similar to mammals. However, there is only one isotype (lineage) of classical class II genes, with one monomorphic DR-like BLA gene and two polymorphic BLB genes, located near one DMA and two DMB genes. The DMB2 and BLB2 genes are widely expressed at high levels, whereas the DMB1 and BLB1 genes are only expressed at highest levels in spleen and intestine, suggesting the possibility of two class II systems in chickens.
dc.description.sponsorshipThis work was supported by a Wellcome Trust programme grant [0 89305/Z/09/Z] and a Wellcome Trust Investigator Award [110106/Z/15/Z] to JK, and the “Gut Health and Food Safety” BBSRC Institute Strategic Programme [BB/J004529/1] for AP.
dc.languageengen
dc.publisherElsevier
dc.titleWhat chickens might tell us about the MHC class II systemen
dc.typeArticle
prism.endingPage29
prism.publicationDate2017en
prism.publicationNameCurrent Opinion in Immunologyen
prism.startingPage23
prism.volume46en
dc.identifier.doi10.17863/CAM.10989
dcterms.dateAccepted2017-03-24en
rioxxterms.versionofrecord10.1016/j.coi.2017.03.013en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-06-01en
dc.contributor.orcidKaufman, Jim [0000-0002-7216-8422]
dc.identifier.eissn1879-0372
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (089305/Z/09/Z)
pubs.funder-project-idWELLCOME TRUST (110106/Z/15/Z)
pubs.funder-project-idBBSRC (BB/D526096/1)
cam.issuedOnline2017-04-21en
rioxxterms.freetoread.startdate2018-04-21


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