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dc.contributor.authorWang, Jen
dc.contributor.authorKreis, Felixen
dc.contributor.authorWright, AJen
dc.contributor.authorHesketh, Richarden
dc.contributor.authorLevitt, MHen
dc.contributor.authorBrindle, Kevinen
dc.date.accessioned2017-06-29T12:14:46Z
dc.date.available2017-06-29T12:14:46Z
dc.date.issued2017-05-05en
dc.identifier.issn0740-3194
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/265093
dc.description.abstract$\textbf{Purpose:}$ Dynamic magnetic resonance spectroscopic imaging of hyperpolarized $^{13}$C-labeled cell substrates has enabled the investigation of tissue metabolism in vivo. Currently observation of these hyperpolarized substrates is limited mainly to $^{13}$C detection. We describe here an imaging pulse sequence that enables proton observation by using polarization transfer from the hyperpolarized $^{13}$C nucleus to spin-coupled protons. $\textbf{Methods:}$ The pulse sequence transfers $^{13}$C hyperpolarization to $^1$H using a modified reverse insensitive nuclei enhanced by polarization transfer (INEPT) sequence that acquires a fully refocused echo. The resulting hyperpolarized $^1$H signal is acquired using a 2D echo-planar trajectory. The efficiency of polarization transfer was investigated using simulations with and without T$_1$ and T$_2$ relaxation of both the $^1$H and $^{13}$C nuclei. $\textbf{Results:}$ Simulations showed that $^1$H detection of the hyperpolarized $^{13}$C nucleus in lactate should increase significantly the signal-to-noise ratio when compared with direct $^{13}$C detection at 3T. However the advantage of $^1$H detection is expected to disappear at higher fields. Dynamic $^1$H images of hyperpolarized [1-$^{13}$C]lactate, with a spatial resolution of 1.25 × 1.25 mm$^2$, were acquired from a phantom injected with hyperpolarized [1-$^{13}$C]lactate and from tumors in vivo following injection of hyperpolarized [1-$^{13}$C]pyruvate. $\textbf{Conclusions:}$ The sequence allows $^1$H imaging of hyperpolarized $^{13}$C-labeled substrates in vivo.
dc.description.sponsorshipGrant sponsor: Cancer Research UK Programme; Grant number: 17242; Grant sponsor: CRUK-EPSRC Imaging Centre in Cambridge and Manchester; Grant number: 16465; Grant sponsor: Danish Strategic Research Council (LIFE-DNP: Hyperpolarized magnetic resonance for in vivo quantification of lipid, sugar and amino acid metabolism in lifestyle related diseases); Grant sponsor: Marie Curie ITN studentship (EUROPOL); Grant number: 642773.
dc.languageengen
dc.language.isoenen
dc.publisherWiley.
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjecthyperpolarizationen
dc.subjectimagingen
dc.subjectlactateen
dc.subjectpyruvateen
dc.titleDynamic $^1$H Imaging of Hyperpolarized [1-$^{13}$C]Lactate In Vivo Using a Reverse INEPT Experimenten
dc.typeArticle
prism.publicationDate2017en
prism.publicationNameMagnetic Resonance in Medicineen
dc.identifier.doi10.17863/CAM.11004
dcterms.dateAccepted2017-03-29en
rioxxterms.versionofrecord10.1002/mrm.26725en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-05-05en
dc.contributor.orcidKreis, Felix [0000-0003-3340-3861]
dc.contributor.orcidHesketh, Richard [0000-0002-8109-0815]
dc.contributor.orcidBrindle, Kevin [0000-0003-3883-6287]
dc.identifier.eissn1522-2594
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (16465)
pubs.funder-project-idCancer Research UK (CB4100)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (642773)
pubs.funder-project-idCancer Research UK (C14303/A17197)
pubs.funder-project-idAarhus University (Source: Data Science Research Centre (DSRC)) (15952)
cam.issuedOnline2017-05-05en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International