Reprogramming human cells to naïve pluripotency: how close are we?
Current Opinion in Genetics and Development
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Bates, L., & Rebelo Da Silva, J. (2017). Reprogramming human cells to naïve pluripotency: how close are we?. Current Opinion in Genetics and Development, 46 58-65. https://doi.org/10.1016/j.gde.2017.06.009
Pluripotent stem cells (PSCs) have the potential to revolutionize biomedical science; however, while it is simple to reproducibly obtain comparable, stable cell lines in mouse, those produced from human material typically show significant variability both within and between cell lines. This is likely due to differences in the cell identity of conventional mouse and human PSCs. It is hoped that recently identified conditions to reprogram human cells to a naïve-like state will produce better PSCs resulting in reproducible experimental outcomes and more consistent differentiation protocols. In this review we discuss the latest literature on the discovery of human naïve-like stem cells and examine how similar they are to both mouse naïve cells and the preimplantation human epiblast.
L.E.B. is the recipient of a MRC PhD studentship and J.C.R.S. of a Wellcome Trust Senior Research Fellowship (WT101861).
Wellcome Trust (101861/Z/13/Z)
External DOI: https://doi.org/10.1016/j.gde.2017.06.009
This record's URL: https://www.repository.cam.ac.uk/handle/1810/265135