Reprogramming human cells to naïve pluripotency: how close are we?
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
Pluripotent stem cells (PSCs) have the potential to revolutionize biomedical science; however, while it is simple to reproducibly obtain comparable, stable cell lines in mouse, those produced from human material typically show significant variability both within and between cell lines. This is likely due to differences in the cell identity of conventional mouse and human PSCs. It is hoped that recently identified conditions to reprogram human cells to a naïve-like state will produce better PSCs resulting in reproducible experimental outcomes and more consistent differentiation protocols. In this review we discuss the latest literature on the discovery of human naïve-like stem cells and examine how similar they are to both mouse naïve cells and the preimplantation human epiblast.
Description
Keywords
Journal Title
Conference Name
Journal ISSN
1879-0380
Volume Title
Publisher
Publisher DOI
Sponsorship
MRC (1509066)
Medical Research Council (MC_PC_12009)