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dc.contributor.authorMoffett, Ashleyen
dc.contributor.authorChazara, Olympeen
dc.contributor.authorColucci, Francescoen
dc.date.accessioned2017-07-10T10:31:25Z
dc.date.available2017-07-10T10:31:25Z
dc.date.issued2017-06en
dc.identifier.issn0015-0282
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/265223
dc.description.abstractImmunological adjustments are needed to accommodate the close contact between two genetically different individuals, the mother and her baby, during mammalian pregnancy. Contact occurs between fetal somatic or placental cells that enter the maternal systemic circulation or between uterine immune cells and the invading extravillous trophoblast. Here we discuss two main types of maternal allo-recognition of the fetus. One depends on avoidance of maternal T cells recognizing and responding to paternally-derived non-self human leukocyte antigens class I and class I allotypes. The other is natural killer allo-recognition where maternally-inherited variable killer immunoglobulin-like receptors expressed by uterine natural killer cells bind to polymorphic fetal human leukocyte antigens-C molecules displayed by extravillous trophoblast. Genetic studies indicate that natural killer cell allo-recognition regulates placentation and the allocation of resources to the fetus.
dc.languageengen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectHLA class I moleculesen
dc.subjectNK cellsen
dc.subjectT cellsen
dc.subjectallo-recognitionen
dc.subjectpregnancyen
dc.titleMaternal allo-recognition of the fetusen
dc.typeArticle
prism.endingPage1272
prism.issueIdentifier6en
prism.publicationDate2017en
prism.publicationNameFertility and Sterilityen
prism.startingPage1269
prism.volume107en
dc.identifier.doi10.17863/CAM.10331
dcterms.dateAccepted2017-05-01en
rioxxterms.versionofrecord10.1016/j.fertnstert.2017.05.001en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2017-06en
dc.contributor.orcidMoffett, Ashley [0000-0002-8388-9073]
dc.contributor.orcidColucci, Francesco [0000-0001-5193-6376]
dc.identifier.eissn1556-5653
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idBritish Heart Foundation (PG/09/077/27964)
pubs.funder-project-idWellcome Trust (200841/Z/16/Z)
cam.issuedOnline2017-05-31en
rioxxterms.freetoread.startdate2018-05-31


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International