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dc.contributor.authorBrzosko, Zuzanna
dc.contributor.authorZannone, S
dc.contributor.authorSchultz, Wolfram
dc.contributor.authorClopath, C
dc.contributor.authorPaulsen, Ole
dc.date.accessioned2017-07-24T14:51:06Z
dc.date.available2017-07-24T14:51:06Z
dc.date.issued2017-07-10
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/265701
dc.description.abstractSpike timing-dependent plasticity (STDP) is under neuromodulatory control, which is correlated with distinct behavioral states. Previously we reported that dopamine, a reward signal, broadens the time window for synaptic potentiation and modulates the outcome of hippocampal STDP even when applied after the plasticity induction protocol (Brzosko et al., 2015). Here we demonstrate that sequential neuromodulation of STDP by acetylcholine and dopamine offers an efficacious model of reward-based navigation. Specifically, our experimental data in mouse hippocampal slices show that acetylcholine biases STDP towards synaptic depression, whilst subsequent application of dopamine converts this depression into potentiation. Incorporating this bidirectional neuromodulation-enabled correlational synaptic learning rule into a computational model yields effective navigation towards changing reward locations, as in natural foraging behavior. Thus, temporally sequenced neuromodulation of STDP enables associations to be made between actions and outcomes and also provides a possible mechanism for aligning the time scales of cellular and behavioral learning.
dc.description.sponsorshipMedical Research Council Studentship Zuzanna Brzosko Wolfram Schultz Ole Paulsen Engineering and Physical Sciences Research Council Studentship Sara Zannone Claudia Clopath Wellcome 095495 Wolfram Schultz Biotechnology and Biological Sciences Research Council BB/N013956/1 Claudia Clopath Wellcome 200790/Z/16/Z Claudia Clopath Biotechnology and Biological Sciences Research Council BB/N019008/1 Ole Paulsen
dc.language.isoen
dc.publishereLife Sciences Publications Ltd
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleSequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation
dc.typeArticle
prism.numbere27756
prism.publicationNameeLife
prism.volume6
dc.identifier.doi10.17863/CAM.11354
dcterms.dateAccepted2017-07-07
rioxxterms.versionofrecord10.7554/eLife.27756
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2017-07-07
dc.contributor.orcidSchultz, Wolfram [0000-0002-8530-4518]
dc.contributor.orcidPaulsen, Ole [0000-0002-2258-5455]
dc.identifier.eissn2050-084X
dc.publisher.urlhttps://elifesciences.org/articles/27756
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (MR/K500781/1)
pubs.funder-project-idWellcome Trust (095495/Z/11/Z)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/N019008/1)
pubs.funder-project-idMRC (1233554)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/P019560/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/N00096X/1)
cam.issuedOnline2017-07-10
dc.identifier.urlhttps://elifesciences.org/articles/27756


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International