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dc.contributor.authorMuka, Ten
dc.contributor.authorOliver-Williams, Clareen
dc.contributor.authorKunutsor, Sen
dc.contributor.authorLaven, JSEen
dc.contributor.authorFauser, BCJMen
dc.contributor.authorChowdhury, Rajiven
dc.contributor.authorKavousi, Men
dc.contributor.authorFranco, OHen
dc.date.accessioned2017-07-27T13:37:51Z
dc.date.available2017-07-27T13:37:51Z
dc.date.issued2016-10-01en
dc.identifier.issn2380-6583
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/265757
dc.description.abstractImportance: As many as 10% of women experience natural menopause by the age of 45 years. If confirmed, an increased risk of cardiovascular disease (CVD) and all-cause mortality associated with premature and early-onset menopause could be an important factor affecting risk of disease and mortality among middle-aged and older women. Objective: To systematically review and meta-analyze studies evaluating the effect of age at onset of menopause and duration since onset of menopause on intermediate CVD end points, CVD outcomes, and all-cause mortality. Data Sources: Medical databases (ie, Medline, EMBASE, and Web of Science) until March 2015. Study Selection: Studies (ie, observational cohort, case-control, or cross-sectional) that assessed age at onset of menopause and/or time since onset of menopause as exposures as well as risk of cardiovascular outcomes and intermediate CVD end points in perimenopausal, menopausal, or postmenopausal women. Data Extraction and Synthesis: Studies were sought if they were observational cohort, case-control, or cross-sectional studies; reported on age at onset of menopause and/or time since onset of menopause as exposures; and assessed associations with risk of CVD-related outcomes, all-cause mortality, or intermediate CVD end points. Data were extracted by 2 independent reviewers using a predesigned data collection form. The inverse-variance weighted method was used to combine relative risks to produce a pooled relative risk using random-effects models to allow for between-study heterogeneity. Main Outcomes and Measures: Cardiovascular disease outcomes (ie, composite CVD, fatal and nonfatal coronary heart disease [CHD], and overall stroke and stroke mortality), CVD mortality, all-cause mortality, and intermediate CVD end points. Results: Of the initially identified references, 32 studies were selected that included 310 329 nonoverlapping women. Outcomes were compared between women who experienced menopause younger than 45 years and women 45 years or older at onset; the relative risks (95% CIs) were 1.50 (1.28-1.76) for overall CHD, 1.11 (1.03-1.20) for fatal CHD, 1.23 (0.98-1.53) for overall stroke, 0.99 (0.92-1.07) for stroke mortality, 1.19 (1.08-1.31) for CVD mortality, and 1.12 (1.03-1.21) for all-cause mortality. Outcomes were also compared between women between 50 and 54 years at onset of menopause and women younger than 50 years at onset; there was a decreased risk of fatal CHD (relative risk, 0.87; 95% CI, 0.80-0.96) and no effect on stroke. Time since onset of menopause in relation to risk of developing intermediate cardiovascular traits or CVD outcomes was reported in 4 observational studies with inconsistent results. Conclusions and Relevance: The findings of this review indicate a higher risk of CHD, CVD mortality, and overall mortality in women who experience premature or early-onset menopause.
dc.description.sponsorshipThis study was sponsored and funded by Metagenics.
dc.languageengen
dc.language.isoenen
dc.publisherAmerican Medical Association
dc.titleAssociation of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular Traits, and All-Cause Mortality: A Systematic Review and Meta-analysisen
dc.typeArticle
prism.endingPage776
prism.issueIdentifier7en
prism.publicationDate2016en
prism.publicationNameJAMA Cardiologyen
prism.startingPage767
prism.volume1en
dc.identifier.doi10.17863/CAM.11425
dcterms.dateAccepted2016-06-16en
rioxxterms.versionofrecord10.1001/jamacardio.2016.2415en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-10-01en
dc.contributor.orcidOliver-Williams, Clare [0000-0002-3573-2426]
dc.contributor.orcidChowdhury, Rajiv [0000-0003-4881-5690]
dc.identifier.eissn2380-6591
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MR/L003120/1)
pubs.funder-project-idMRC (G0800270)
pubs.funder-project-idBritish Heart Foundation (RG/08/014/24067)
pubs.funder-project-idBritish Heart Foundation (RG/13/13/30194)


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