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dc.contributor.authorCaygill, EE
dc.contributor.authorBrand, AH
dc.date.accessioned2017-07-31T11:36:54Z
dc.date.available2017-07-31T11:36:54Z
dc.date.issued2017-08-08
dc.identifier.issn2211-1247
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/265786
dc.description.abstractThe 40,000 neurons of the medulla, the largest visual processing center of the $\textit{Drosophila}$ brain, derive from a sheet of neuroepithelial cells. During larval development, a wave of differentiation sweeps across the neuroepithelium, converting neuroepithelial cells into neuroblasts that sequentially express transcription factors specifying different neuronal cell fates. The switch from neuroepithelial cells to neuroblasts is controlled by a complex gene regulatory network and is marked by the expression of the proneural gene $\textit{l’sc}$. We discovered that microRNA $\textit{miR-7}$ is expressed at the transition between neuroepithelial cells and neuroblasts. We showed that $\textit{miR-7}$ promotes neuroepithelial cell-to-neuroblast transition by targeting downstream Notch effectors to limit Notch signaling. $\textit{miR-7}$ acts as a buffer to ensure that a precise and stereotypical pattern of transition is maintained, even under conditions of environmental stress, echoing the role that $\textit{miR-7}$ plays in the eye imaginal disc. This common mechanism reflects the importance of robust visual system development.
dc.description.sponsorshipThis work was funded by a Wellcome Trust Programme grant (092545), a Wellcome Trust Senior Investigator Award (103792), and a BBSRC Project Grant (BB/L007800/1) to A.H.B. A.H.B. acknowledges core funding to the Gurdon Institute from the Wellcome Trust (092096) and CRUK (C6946/A14492).
dc.language.isoen
dc.publisherElsevier
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titlemiR-7 Buffers Differentiation in the Developing Drosophila Visual System
dc.typeArticle
prism.endingPage1261
prism.issueIdentifier6
prism.publicationDate2017
prism.publicationNameCell Reports
prism.startingPage1255
prism.volume20
dc.identifier.doi10.17863/CAM.12026
dcterms.dateAccepted2017-07-18
rioxxterms.versionofrecord10.1016/j.celrep.2017.07.047
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2017-08-08
dc.contributor.orcidBrand, Andrea [0000-0002-2089-6954]
dc.identifier.eissn2211-1247
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (092545/Z/10/Z)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/L007800/1)
pubs.funder-project-idWellcome Trust (103792/Z/14/Z)
pubs.funder-project-idRoyal Society (RP150061)
pubs.funder-project-idWellcome Trust (092096/Z/10/Z)
pubs.funder-project-idCancer Research Uk (None)
cam.issuedOnline2017-08-08
cam.orpheus.successThu Jan 30 12:53:28 GMT 2020 - The item has an open VoR version.
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International