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dc.contributor.authorPallipurath, ARen
dc.contributor.authorCivati, Fen
dc.contributor.authorSibik, Jen
dc.contributor.authorCrowley, Cen
dc.contributor.authorZeitler, Axelen
dc.contributor.authorMcArdle, Pen
dc.contributor.authorErxleben, Aen
dc.date.accessioned2017-08-04T15:14:41Z
dc.date.available2017-08-04T15:14:41Z
dc.date.issued2017-06-08en
dc.identifier.issn0378-5173
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/265925
dc.description.abstractUnderstanding phase transitions in pharmaceutical materials is of vital importance for drug manufacturing, processing and storage. In this paper we have carried out comprehensive high-resolution spectroscopic studies on the polymorphs of the non-steroidal anti-inflammatory drug diflunisal that has four known polymorphs, forms I-IV (FI-FIV), three of which have known crystal structures. Phase transformations during milling, heating, melt-quenching and exposure to high relative humidity were investigated using Raman and terahertz spectroscopy in combination with differential scanning calorimetry and X-ray powder diffraction. The observed phase transformations indicate the stability order FIII>FI>FII, FIV. Furthermore, crystallization experiments from the gas phase and from solution by fast evaporation of different solvents were carried out. Fast evaporation of an ethanolic solution below 70°C was identified as a reliable and convenient method to obtain the somewhat elusive FII in bulk quantities.
dc.description.sponsorshipThis work was supported by Science Foundation Ireland under Grant No. [12/RC/2275] as part of the Synthesis and Solid State Pharmaceutical Centre (SSPC). ARP would like to acknowledge ICHEC, Irish HPC system for computing time on the condominium access (nuig02). ARP also acknowledges the RIA Charlemont grant for financial support of a research visit to the University of Cambridge.
dc.languageengen
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectdiflunisalen
dc.subjectphase transformationen
dc.subjectpolymorphsen
dc.subjectterahertz spectroscopyen
dc.titleA comprehensive spectroscopic study of the polymorphs of diflunisal and their phase transformationsen
dc.typeArticle
prism.endingPage321
prism.issueIdentifier1-2en
prism.publicationDate2017en
prism.publicationNameInternational Journal of Pharmaceuticsen
prism.startingPage312
prism.volume528en
dc.identifier.doi10.17863/CAM.10409
dcterms.dateAccepted2017-06-07en
rioxxterms.versionofrecord10.1016/j.ijpharm.2017.06.020en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2017-06-08en
dc.contributor.orcidZeitler, Axel [0000-0002-4958-0582]
dc.identifier.eissn1873-3476
rioxxterms.typeJournal Article/Reviewen
cam.issuedOnline2017-06-08en
rioxxterms.freetoread.startdate2018-06-08


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International