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dc.contributor.authorChennu, Srivasen
dc.contributor.authorBekinschtein, Tristanen
dc.date.accessioned2017-08-08T12:24:35Z
dc.date.available2017-08-08T12:24:35Z
dc.date.issued2012-03-05en
dc.identifier.issn1664-1078
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/266020
dc.description.abstractThe interplay between attention and consciousness is frequently tested in altered states of consciousness, including transitions between stages of sleep and sedation, and in pathological disorders of consciousness (DoC; the vegetative and minimally conscious states; VS and MCS). One of the most widely used tasks to assess cognitive processing in this context is the auditory oddball paradigm, where an infrequent change in a sequence of sounds elicits, in awake subjects, a characteristic EEG event-related potential called the mismatch negativity, followed by the classic P300 wave. The latter is further separable into the slightly earlier, anterior P3a and the later, posterior P3b, thought to be linked to task-irrelevant "bottom-up" and task-oriented "top-down" attention, respectively. We discuss here the putative dissociations between attention and awareness in DoC, sedation and sleep, bearing in mind the recently emerging evidence from healthy volunteers and patients. These findings highlight the neurophysiological and cognitive parallels (and differences) across these three distinct variations in levels of consciousness, and inform the theoretical framework for interpreting the role of attention therein.
dc.description.sponsorshipThis research was supported by generous funding from the Medical Research Council (U.1055.01.002.00001.01), the James S. McDonnell Foundation, and the Wellcome Trust Biomedical Research Fellowship awarded to Tristan A. Bekinschtein.
dc.languageengen
dc.publisherFrontiers Media
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectP300en
dc.subjectarousalen
dc.subjectattention and awarenessen
dc.subjectdisorders of consciousnessen
dc.subjectmismatch negativityen
dc.subjectsedationen
dc.subjectsleepen
dc.titleArousal modulates auditory attention and awareness: insights from sleep, sedation, and disorders of consciousness.en
dc.typeArticle
prism.endingPage65
prism.publicationDate2012en
prism.publicationNameFrontiers in Psychologyen
prism.startingPage65
prism.volume3en
dc.identifier.doi10.17863/CAM.10232
dcterms.dateAccepted2012-02-18en
rioxxterms.versionofrecord10.3389/fpsyg.2012.00065en
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc/4.0/en
rioxxterms.licenseref.startdate2012-03-05en
dc.contributor.orcidBekinschtein, Tristan [0000-0001-5501-8628]
dc.identifier.eissn1664-1078
rioxxterms.typeJournal Article/Reviewen
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fpsyg.2012.00065/full#h10en


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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International