Maternal diet, aging and diabetes meet at a chromatin loop.
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Peer-reviewed
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Abstract
We have recently demonstrated that exposure to a suboptimal diet during early development leads to abnormal epigenetic regulation of a promoter-enhancer interaction at the gene encoding HNF-4α, a key transcription factor required for pancreatic β-cell differentiation and glucose homeostasis. In addition, our studies revealed that the suboptimal maternal diet amplifies the age-associated epigenetic silencing of this locus. In this research perspective we discuss these novel findings in the context of the growing list of epigenetic mechanisms by which the environment can affect gene activity and emphasize their implications for the understanding of the mechanistic basis of the development of type 2 diabetes with age.
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Keywords
Aging, Animals, Chromatin, Diabetes Mellitus, Type 2, Diet, Enhancer Elements, Genetic, Epigenesis, Genetic, Female, Gene Expression Regulation, Hepatocyte Nuclear Factor 4, Humans, Insulin-Secreting Cells, Pregnancy, Prenatal Exposure Delayed Effects, Promoter Regions, Genetic
Journal Title
Aging (Albany NY)
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Journal ISSN
1945-4589
1945-4589
1945-4589
Volume Title
3
Publisher
Impact Journals, LLC
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Sponsorship
Biotechnology and Biological Sciences Research Council (BB/D007909/1)
Biotechnology and Biological Sciences Research Council (BB/D01235X/2)
Biotechnology and Biological Sciences Research Council (BB/E002161/1)
British Heart Foundation (None)
Medical Research Council (G0600717)
Biotechnology and Biological Sciences Research Council (BB/F015364/1)
Medical Research Council (G0600717/1)
Biotechnology and Biological Sciences Research Council (BB/D01235X/2)
Biotechnology and Biological Sciences Research Council (BB/E002161/1)
British Heart Foundation (None)
Medical Research Council (G0600717)
Biotechnology and Biological Sciences Research Council (BB/F015364/1)
Medical Research Council (G0600717/1)
This work was supported by the Biotechnology and Biological Sciences Research Council, the British Heart Foundation, the FP6 Epigenome Network of Excellence programme, GlaxoSmithKline, the Nuffield Foundation, the Royal Society, the National Institute for Health Research Cambridge Biomedical Research Centre, and the Medical Research Council Centre for Obesity and Related Metabolic Diseases