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dc.contributor.authorXu, Shu ping
dc.contributor.authorYang, Yan yan
dc.contributor.authorXue, Dan
dc.contributor.authorLiu, Jin xiu
dc.contributor.authorLiu, Xin min
dc.contributor.authorFan, Tai-Ping
dc.contributor.authorPan, Rui le
dc.contributor.authorLi, PengTao
dc.date.accessioned2017-08-11T13:56:50Z
dc.date.available2017-08-11T13:56:50Z
dc.date.issued2011-3-6
dc.identifier.citationShu ping Xu, Yan yan Yang, Dan Xue, et al., “Cognitive-Enhancing Effects of Polygalasaponin Hydrolysate in Aβ25–35-Induced Amnesic Mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 839720, 12 pages, 2011. doi:10.1155/2011/839720
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/266298
dc.description.abstractPolygalasaponins are the major active constituents of Polygala tenuifolia exhibiting antiamnesic activity, but their applications are limited due to their toxicities. Evidence showed that the toxicities can be attenuated by hydrolysis. Herein, effects of a hydrolysate of polygalasaponins (HPS) on cognitive impairment induced by Aβ25−35 were assessed by Morris water maze and step-through passive avoidance tests. The impaired spatial reference memory was improved by HPS (50 and 100 mg/kg). In the acquisition trial of step-through test, HPS (50 and 100 mg/kg) increased the latency into the dark chamber and decreased the error frequency significantly (). However, no significant change was observed during the retention trial. Additionally, HPS increased the corresponding SOD activities (62.34%, 22.09%) and decreased MDA levels (28.21%, 32.35%) in both cortex and hippocampus as compared to model animals. These results show that HPS may be a useful treatment against amnesia probably via its antioxidant properties.
dc.rightsAll Rights Reserveden
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved/en
dc.titleCognitive-Enhancing Effects of Polygalasaponin Hydrolysate in Aβ25–35-Induced Amnesic Mice
dc.typeArticle
dc.date.updated2017-07-18T08:24:56Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderCopyright © 2011 Shu ping Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.identifier.doi10.17863/CAM.12560
rioxxterms.versionofrecord10.1155/2011/839720


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