T-ALL: several homes rather than homeless?
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Publication Date
2017-01Journal Title
Immunology and Cell Biology
ISSN
0818-9641
Publisher
Springer Nature
Volume
95
Issue
1
Pages
1-2
Language
English
Type
Article
This Version
VoR
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Rak, J., & Mendez-Ferrer, S. (2017). T-ALL: several homes rather than homeless?. Immunology and Cell Biology, 95 (1), 1-2. https://doi.org/10.1038/icb.2016.103
Abstract
Microenvironment-targeted therapies are emerging as possible complementary approaches to treat malignancies. However, progress is hindered by the complexity of the interactions between malignant cells and their microenvironment. In leukemia, this complexity is further emphasized by a highly dynamic behavior of leukemic cells recently reported in Nature. Hawkins et al.1 analyze leukemic cell localization relative to microenvironmental cells in T-cell acute lymphoblastic leukemia (T-ALL) through real-time intravital imaging. Contrasting previous studies, Lo Celso and colleagues report a highly motile behavior and lack of stable interactions with specific microenvironmental cell types during disease progression or after chemotherapy. This study challenges some current concepts on microenvironmental dependence of leukemia.
Sponsorship
MRC (MC_PC_12009)
Funder references
MRC (MC_PC_12009)
ECH2020 EUROPEAN RESEARCH COUNCIL (ERC) (648765)
Identifiers
External DOI: https://doi.org/10.1038/icb.2016.103
This record's URL: https://www.repository.cam.ac.uk/handle/1810/266452
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