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dc.contributor.authorAragona, Mariacelesteen
dc.contributor.authorDekoninck, Sophieen
dc.contributor.authorRulands, Steffenen
dc.contributor.authorLenglez, Sandrineen
dc.contributor.authorMascré, Guilhemen
dc.contributor.authorSimons, Benjaminen
dc.contributor.authorBlanpain, Cédricen
dc.date.accessioned2017-08-17T10:10:41Z
dc.date.available2017-08-17T10:10:41Z
dc.date.issued2017-03-01en
dc.identifier.issn2041-1723
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/266536
dc.description.abstractWound healing is essential to repair the skin after injury. In the epidermis, distinct stem cells (SCs) populations contribute to wound healing. However, how SCs balance proliferation, differentiation and migration to repair a wound remains poorly understood. Here, we show the cellular and molecular mechanisms that regulate wound healing in mouse tail epidermis. Using a combination of proliferation kinetics experiments and molecular profiling, we identify the gene signatures associated with proliferation, differentiation and migration in different regions surrounding the wound. Functional experiments show that SC proliferation, migration and differentiation can be uncoupled during wound healing. Lineage tracing and quantitative clonal analysis reveal that, following wounding, progenitors divide more rapidly, but conserve their homoeostatic mode of division, leading to their rapid depletion, whereas SCs become active, giving rise to new progenitors that expand and repair the wound. These results have important implications for tissue regeneration, acute and chronic wound disorders.
dc.description.sponsorshipThis work was supported by the FNRS, TELEVIE, the PAI programme, a research grant from the Fondation contre le Cancer, the ULB fondation, the foundation Bettencourt Schueller, the foundation Baillet Latour and a consolidator grant the European Research Council (ERC-EXPAND).
dc.languageengen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectAnimalsen
dc.subjectCell Movementen
dc.subjectCell Polarityen
dc.subjectCell Proliferationen
dc.subjectCell Shapeen
dc.subjectClone Cellsen
dc.subjectEpidermisen
dc.subjectHair Follicleen
dc.subjectMiceen
dc.subjectModels, Biologicalen
dc.subjectStem Cellsen
dc.subjectWound Healingen
dc.titleDefining stem cell dynamics and migration during wound healing in mouse skin epidermis.en
dc.typeArticle
prism.number14684en
prism.publicationDate2017en
prism.publicationNameNature Communicationsen
prism.volume8en
dc.identifier.doi10.17863/CAM.10414
dcterms.dateAccepted2017-01-23en
rioxxterms.versionofrecord10.1038/ncomms14684en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-03-01en
dc.contributor.orcidRulands, Steffen [0000-0001-6398-1553]
dc.contributor.orcidSimons, Benjamin [0000-0002-3875-7071]
dc.identifier.eissn2041-1723
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_PC_12009)
dc.identifier.urlhttps://www.nature.com/articles/ncomms14684en


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International