Show simple item record

dc.contributor.authorHockman, Den
dc.contributor.authorBurns, AJen
dc.contributor.authorSchlosser, Gen
dc.contributor.authorGates, KPen
dc.contributor.authorJevans, Ben
dc.contributor.authorMongera, Aen
dc.contributor.authorFisher, Sen
dc.contributor.authorUnlu, Gen
dc.contributor.authorKnapik, EWen
dc.contributor.authorKaufman, CKen
dc.contributor.authorMosimann, Cen
dc.contributor.authorZon, LIen
dc.contributor.authorLancman, JJen
dc.contributor.authorDong, PDSen
dc.contributor.authorLickert, Hen
dc.contributor.authorTucker, ASen
dc.contributor.authorBaker, Clareen
dc.date.accessioned2017-08-21T10:33:21Z
dc.date.available2017-08-21T10:33:21Z
dc.date.issued2017-04-07en
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/266670
dc.description.abstractThe evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes - carotid body glomus cells, and 'pulmonary neuroendocrine cells' (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive 'neuroepithelial cells' (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches.
dc.description.sponsorshipThis work was funded by the Wellcome Trust (Ph.D. Studentship 086804/Z/08/Z to DH; Senior Investigator Award 102889/Z/13/Z to AST), the NIDCR/NIH (R21-DE021509 to SF; R01-DE018477 to EWK), the NIDDK/NIH (1DP2DK098092 to PDSD), the NIH (R01-HL092217 to EWK), the Zebrafish Initiative of the Vanderbilt University Academic Venture Capital Fund (to EWK), the Vanderbilt International Scholar Program (to GU), the HFSP (Long-Term Fellowship to CM) and the Swiss National Science Foundation (Advanced Postdoctoral Fellowship and Professorship to CM). For further information, please visit the publisher's website.
dc.languageengen
dc.language.isoenen
dc.publishereLife
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectcarotid bodyen
dc.subjectchickenen
dc.subjectdevelopmental biologyen
dc.subjectendodermen
dc.subjectfate-mappingen
dc.subjectmouseen
dc.subjectneural cresten
dc.subjectneuroepithelial cellsen
dc.subjectsea lamprey (Petromyzon marinus)en
dc.subjectstem cellsen
dc.subjectxenopusen
dc.subjectzebrafishen
dc.titleEvolution of the hypoxia-sensitive cells involved in amniote respiratory reflexesen
dc.typeArticle
prism.numbere21231en
prism.publicationDate2017en
prism.publicationNameElifeen
prism.volume6en
dc.identifier.doi10.17863/CAM.12749
dcterms.dateAccepted2017-04-07en
rioxxterms.versionofrecord10.7554/eLife.21231en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-04-07en
dc.contributor.orcidBaker, Clare [0000-0002-4434-3107]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWellcome Trust (086804/Z/08/Z)
cam.orpheus.successThu Jan 30 13:00:26 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International