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dc.contributor.authorNelson, CPen
dc.contributor.authorGoel, Aen
dc.contributor.authorButterworth, Adamen
dc.contributor.authorKanoni, Sen
dc.contributor.authorWebb, TRen
dc.contributor.authorMarouli, Een
dc.contributor.authorZeng, Len
dc.contributor.authorNtalla, Ien
dc.contributor.authorLai, FYen
dc.contributor.authorHopewell, JCen
dc.contributor.authorGiannakopoulou, Oen
dc.contributor.authorJiang, Taoen
dc.contributor.authorHamby, SEen
dc.contributor.authorDi Angelantonio, Emanueleen
dc.contributor.authorAssimes, TLen
dc.contributor.authorBottinger, EPen
dc.contributor.authorChambers, JCen
dc.contributor.authorClarke, Ren
dc.contributor.authorPalmer, CNAen
dc.contributor.authorCubbon, RMen
dc.contributor.authorEllinor, Pen
dc.contributor.authorErmel, Ren
dc.contributor.authorEvangelou, Een
dc.contributor.authorFranks, PWen
dc.contributor.authorGrace, Cen
dc.contributor.authorGu, Den
dc.contributor.authorHingorani, ADen
dc.contributor.authorHowson, Joannaen
dc.contributor.authorIngelsson, Een
dc.contributor.authorKastrati, Aen
dc.contributor.authorKessler, Ten
dc.contributor.authorKyriakou, Ten
dc.contributor.authorLehtimäki, Ten
dc.contributor.authorLu, Xen
dc.contributor.authorLu, Yen
dc.contributor.authorMärz, Wen
dc.contributor.authorMcPherson, Ren
dc.contributor.authorMetspalu, Aen
dc.contributor.authorPujades-Rodriguez, Men
dc.contributor.authorRuusalepp, Aen
dc.contributor.authorSchadt, EEen
dc.contributor.authorSchmidt, AFen
dc.contributor.authorSweeting, Michaelen
dc.contributor.authorZalloua, PAen
dc.contributor.authorAlGhalayini, Ken
dc.contributor.authorKeavney, BDen
dc.contributor.authorKooner, JSen
dc.contributor.authorLoos, RJFen
dc.contributor.authorPatel, RSen
dc.contributor.authorRutter, MKen
dc.contributor.authorTomaszewski, Men
dc.contributor.authorTzoulaki, Ien
dc.contributor.authorZeggini, Een
dc.contributor.authorErdmann, Jen
dc.contributor.authorDedoussis, Gen
dc.contributor.authorBjörkegren, JLMen
dc.contributor.authorEPIC-CVD Consortium,en
dc.contributor.authorCARDIoGRAMplusC4D,en
dc.contributor.authorUK Biobank CardioMetabolic Consortium CHD working group,en
dc.contributor.authorSchunkert, Hen
dc.contributor.authorFarrall, Men
dc.contributor.authorDanesh, Johnen
dc.contributor.authorSamani, NJen
dc.contributor.authorWatkins, Hen
dc.contributor.authorDeloukas, Pen
dc.date.accessioned2017-08-21T11:09:25Z
dc.date.available2017-08-21T11:09:25Z
dc.identifier.issn1061-4036
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/266676
dc.description.abstractGenome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10(-8)) at the time of this analysis, but a much larger number of putative loci at a false discovery rate (FDR) of 5% (refs. 1,2,3,4). Here we leverage an interim release of UK Biobank (UKBB) data to evaluate the validity of the FDR approach. We tested a CAD phenotype inclusive of angina (SOFT; ncases = 10,801) as well as a stricter definition without angina (HARD; ncases = 6,482) and selected cases with the former phenotype to conduct a meta-analysis using the two most recent CAD GWAS. This approach identified 13 new loci at genome-wide significance, 12 of which were on our previous list of loci meeting the 5% FDR threshold, thus providing strong support that the remaining loci identified by FDR represent genuine signals. The 304 independent variants associated at 5% FDR in this study explain 21.2% of CAD heritability and identify 243 loci that implicate pathways in blood vessel morphogenesis as well as lipid metabolism, nitric oxide signaling and inflammation.
dc.description.sponsorshipFor funding information please visit the publisher's website.
dc.languageengen
dc.language.isoenen
dc.publisherNature Publishing Group
dc.subjectcardiovascular diseasesen
dc.subjectgeneticsen
dc.subjectgenome-wide association studiesen
dc.subjectsequence annotationen
dc.titleAssociation analyses based on false discovery rate implicate new loci for coronary artery diseaseen
dc.typeArticle
prism.publicationNameNature Geneticsen
dc.identifier.doi10.17863/CAM.12752
dcterms.dateAccepted2017-06-15en
rioxxterms.versionofrecord10.1038/ng.3913en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-06-15en
dc.contributor.orcidButterworth, Adam [0000-0002-6915-9015]
dc.contributor.orcidDi Angelantonio, Emanuele [0000-0001-8776-6719]
dc.contributor.orcidHowson, Joanna [0000-0001-7618-0050]
dc.contributor.orcidSweeting, Michael [0000-0003-0980-8965]
dc.contributor.orcidDanesh, John [0000-0003-1158-6791]
dc.identifier.eissn1546-1718
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (G0800270)
pubs.funder-project-idMRC (MR/L003120/1)
pubs.funder-project-idBritish Heart Foundation (RG/08/014/24067)
cam.issuedOnline2017-07-17en
rioxxterms.freetoread.startdate2018-01-17


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