Learning predictive statistics: strategies and brain mechanisms
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Journal Title
Journal of Neuroscience
ISSN
0270-6474
Publisher
Society for Neuroscience
Volume
37
Issue
35
Pages
8412-8427
Language
English
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Wang, R., Shen, Y., Tino, P., Welchman, A., & Kourtzi, Z. (2017). Learning predictive statistics: strategies and brain mechanisms. Journal of Neuroscience, 37 (35), 8412-8427. https://doi.org/10.1523/JNEUROSCI.0144-17.2017
Abstract
When immersed in a new environment we are challenged to decipher initially incomprehensible streams of sensory information. Yet, quite rapidly, the brain finds structure and meaning in these incoming signals, helping us to predict and prepare ourselves for future actions. This skill relies on extracting the statistics of event streams in the environment that contain regularities of variable complexity: from simple repetitive patterns to complex probabilistic combinations. Here, we test the brain mechanisms that mediate our ability to adapt to the environment's statistics and predict upcoming events. By combining behavioral training and multi-session fMRI in human participants (male and female), we track the cortico-striatal mechanisms that mediate learning of temporal sequences as they change in structure complexity. We show that learning of predictive structures relates to individual decision strategy; that is, selecting the most probable outcome in a given context (maximizing) vs. matching the exact sequence statistics. These strategies engage distinct human brain regions: maximizing engages dorsolateral prefrontal, cingulate, sensory-motor regions and basal ganglia (dorsal caudate, putamen), while matching engages occipito-temporal regions (including the hippocampus) and basal ganglia (ventral caudate). Our findings provide evidence for distinct cortico-striatal mechanisms that facilitate our ability to extract behaviorally-relevant statistics to make predictions.SIGNIFICANCE STATEMENTMaking predictions about future events relies on interpreting streams of information that may initially appear incomprehensible. Past work has studied how humans identify repetitive patterns and associative pairings. However, the natural environment contains regularities that vary in complexity: from simple repetition to complex probabilistic combinations. Here, we combine behavior and multi-session fMRI to track the brain mechanisms that mediate our ability to adapt to changes in the environment's statistics. We provide evidence for an alternate route for learning complex temporal statistics: extracting the most probable outcome in a given context is implemented by interactions between executive and motor cortico-striatal mechanisms compared to visual cortico-striatal circuits (including hippocampal cortex) that support learning of the exact temporal statistics.
Sponsorship
This work was supported by grants to PT from Engineering and Physical Sciences Research Council [EP/ L000296/1], ZK from the Biotechnology and Biological Sciences Research Council [H012508], the Leverhulme Trust [RF-2011-378] and the [European Community's] Seventh Framework Programme [FP7/2007-2013] under agreement PITN-GA 2011-290011, AEW from the Wellcome Trust (095183/Z/10/Z).
Funder references
Wellcome Trust (095183/B/10/Z)
European Commission (290011)
Leverhulme Trust (RF-2011-378)
Identifiers
External DOI: https://doi.org/10.1523/JNEUROSCI.0144-17.2017
This record's URL: https://www.repository.cam.ac.uk/handle/1810/266706