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dc.contributor.authorHovorka, R
dc.contributor.authorTauschmann, M
dc.date.accessioned2017-08-29T12:07:45Z
dc.date.available2017-08-29T12:07:45Z
dc.date.issued2017-12
dc.identifier.issn1742-5247
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/266918
dc.description.abstract$\textbf{Introduction:}$ Nocturnal glucose control remains challenging in children and adolescents with type 1 diabetes due to highly variable overnight insulin requirements. The issue may be addressed by glucose responsive insulin delivery based on real-time continuous glucose measurements. $\textbf{Areas covered:}$ This review outlines recent developments of glucose responsive insulin delivery systems from a paediatric perspective. We cover threshold-based suspend application, predictive low glucose suspend, and more advanced single hormone and dual-hormone closed-loop systems. Approaches are evaluated in relation to nocturnal glucose control particularly during outpatient randomised controlled trials. $\textbf{Expert opinion:}$ Significant progress translating research from controlled clinical centre settings to free-living unsupervised home studies have been achieved over the past decade. Nocturnal glycaemic control can be improved whilst reducing the risk of hypoglycaemia with closed-loop systems. Following the US regulatory approval of the first hybrid closed-loop system in non-paediatric population, large multinational closed-loop clinical trials and pivotal studies including paediatric populations are underway or in preparation to facilitate the use of closed-loop systems in clinical practice.
dc.description.sponsorshipEC Horizon 2020 [H2020-SC1-731560], JDRF [2-SRA-2014-256-M-R], National Institute of Diabetes and Digestive and Kidney Diseases [1UC4DK108520-01], National Institute for Health Research Cambridge Biomedical Research Centre, Wellcome Trust Strategic Award [100574/Z/12/Z], Efficacy and Mechanism Evaluation National Institute for Health Research [14/23/09].
dc.language.isoen
dc.publisherTaylor & Francis
dc.subjectthreshold-based insulin interruption
dc.subjectlow glucose suspension
dc.subjectpredictive low glucose suspension
dc.subjectartificial pancreas
dc.subjectclosed-loop system
dc.subjecttype 1 diabetes
dc.subjectcontrol algorithm
dc.subjectinsulin pump
dc.subjectcontinuous glucose monitor
dc.titleInsulin delivery and nocturnal glucose control in children and adolescents with type 1 diabetes
dc.typeArticle
prism.publicationNameExpert Opinion on Drug Delivery
dc.identifier.doi10.17863/CAM.12028
dcterms.dateAccepted2017-07-25
rioxxterms.versionofrecord10.1080/17425247.2017.1360866
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-07-25
dc.contributor.orcidHovorka, Roman [0000-0003-2901-461X]
dc.contributor.orcidTauschmann, Martin [0000-0002-2305-2490]
dc.identifier.eissn1744-7593
rioxxterms.typeJournal Article/Review
pubs.funder-project-idNational Institute for Health Research (NIHR) (unknown)
pubs.funder-project-idWellcome Trust (100574/Z/12/Z)
pubs.funder-project-idJuvenile Diabetes Research Foundation Ltd (JDRF) (2-SRA-2014-256-M-R)
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Societal Challenges (731560)
pubs.funder-project-idNational Institute of Diabetes and Digestive and Kidney Diseases (UC4DK108520)
cam.issuedOnline2017-08-18
rioxxterms.freetoread.startdate2018-08-18


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