Show simple item record

dc.contributor.authorRoberts, Angelaen
dc.contributor.authorShiba, Yen
dc.contributor.authorOikonomidis, Len
dc.contributor.authorSawiak, Stephenen
dc.contributor.authorFryer, Timothyen
dc.contributor.authorHong, Youngen
dc.contributor.authorCockcroft, Gemmaen
dc.contributor.authorSantangelo, Andrea Marianaen
dc.date.accessioned2017-08-30T07:37:49Z
dc.date.available2017-08-30T07:37:49Z
dc.date.issued2017-12-15en
dc.identifier.issn0006-3223
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/266937
dc.description.abstractBACKGROUND: Impaired regulation of emotional responses to potential threat is a core feature of affective disorders. However, while the subcortical circuitry responsible for processing and expression of fear has been well characterized, the top-down control of this circuitry is less well understood. Our recent studies demonstrated that heightened emotionality, as measured both physiologically and behaviorally, during conditioned fear and innate/ social threat was induced, independently, by excitotoxic lesions of either the anterior orbitofrontal cortex (antOFC) or ventrolateral prefrontal cortex (vlPFC). An important outstanding question is whether the antOFC and vlPFC act on common or distinct downstream targets to regulate negative emotion. METHODS: The question was addressed by combining localized excitotoxic lesions in the PFC of a nonhuman primate and functional neuroimaging ([$^{18}$F]fluorodeoxyglucose positron emission tomography) with a fear-regulating extinction paradigm. Marmoset monkeys with unilateral lesions of either the antOFC or vlPFC were scanned immediately following exposure to a fearful or safe context, and differences in [$^{18}$F]fluorodeoxyglucose uptake were evaluated. RESULTS: [$^{18}$F]fluorodeoxyglucose uptake in the insula and amygdala of the intact hemisphere was significantly increased in response to the fearful context compared with the safe context. Such discrimination between the two contexts was not reflected in the activity of the insula-amygdala of the antOFC or vlPFC-lesioned hemisphere. Instead, uptake was at an intermediate level in both contexts. CONCLUSIONS: These findings demonstrate that the distinct control functions of the antOFC and vlPFC converge on the same downstream targets to promote emotion regulation, taking us closer to a mechanistic understanding of different forms of anxiety.
dc.description.sponsorshipThis research was supported by a Medical Research Programme Grant (No. MR/M023990/1) from the Medical Research Council (to ACR) and was carried out within the Behavioural and Clinical Neuroscience Institute supported by a consortium award from the Wellcome Trust and the Medical Research Council.
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectamygdalaen
dc.subjectemotion regulationen
dc.subjectinsulaen
dc.subjectorbitofrontal cortexen
dc.subjectprefrontal cortexen
dc.subjectventrolateral prefrontal cortexen
dc.titleConverging Prefronto-Insula-Amygdala Pathways in Negative Emotion Regulation in Marmoset Monkeysen
dc.typeArticle
prism.endingPage903
prism.issueIdentifier12en
prism.publicationDate2017en
prism.publicationNameBiological Psychiatryen
prism.startingPage895
prism.volume82en
dc.identifier.doi10.17863/CAM.10359
dcterms.dateAccepted2017-06-10en
rioxxterms.versionofrecord10.1016/j.biopsych.2017.06.016en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-12-15en
dc.contributor.orcidRoberts, Angela [0000-0003-2873-157X]
dc.contributor.orcidSawiak, Stephen [0000-0003-4210-9816]
dc.contributor.orcidSantangelo, Andrea Mariana [0000-0001-7727-2651]
dc.identifier.eissn1873-2402
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMedical Research Council (MR/M023990/1)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (G0001354)
pubs.funder-project-idMRC (G1000183)
cam.issuedOnline2017-06-23en
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0006322317317158?via%3Dihub#!en
rioxxterms.freetoread.startdate2100-01-01


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International