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dc.contributor.authorIto, Yokoen
dc.contributor.authorHoare, Matthewen
dc.contributor.authorNarita, Masashien
dc.date.accessioned2017-09-26T15:19:20Z
dc.date.available2017-09-26T15:19:20Z
dc.date.issued2017-11en
dc.identifier.issn0962-8924
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267419
dc.description.abstractCellular senescence is an autonomous tumor suppressor mechanism leading to a stable cell cycle arrest. Senescent cells are highly secretory driving a range of different functions through the senescence-associated secretory phenotype (SASP). Recent findings have suggested that the composition of the SASP is dynamically and spatially regulated and that the changing composition of the SASP can determine the beneficial and detrimental aspects of the senescence program, tipping the balance to either an immunosuppressive/pro-fibrotic environment or pro-inflammatory/fibrolytic state. Here we discuss the current understanding of the temporal and spatial regulation of the SASP and the novel finding of NOTCH signaling as a regulator of SASP composition.
dc.description.sponsorshipY.I. and M.N. are supported by a Cancer Research UK Cambridge Centre Core Grant (C14303/A17197). M.H. is supported by a CRUK Clinician Scientist Fellowship (C52489/A19924).
dc.language.isoenen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectsenescenceen
dc.subjectsenescence-associated secretory phenotype (SASP)en
dc.subjectinflammationen
dc.subjectC/EBPβen
dc.subjectNOTCHen
dc.subjectlateral inductionen
dc.titleSpatial and Temporal Control of Senescenceen
dc.typeArticle
prism.endingPage832
prism.issueIdentifier11en
prism.publicationDate2017en
prism.publicationNameTrends in Cell Biologyen
prism.startingPage820
prism.volume27en
dc.identifier.doi10.17863/CAM.12187
dcterms.dateAccepted2017-07-21en
rioxxterms.versionofrecord10.1016/j.tcb.2017.07.004en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2017-11en
dc.contributor.orcidHoare, Matthew [0000-0001-5990-9604]
dc.contributor.orcidNarita, Masashi [0000-0001-7764-577X]
dc.identifier.eissn1879-3088
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idCancer Research UK (C14303_do not transfer)
pubs.funder-project-idCancer Research UK (19924)
pubs.funder-project-idCancer Research UK (CB4210)
pubs.funder-project-idCancer Research UK (CRUK-A19924)
cam.issuedOnline2017-08-17en
rioxxterms.freetoread.startdate2018-08-17


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International