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dc.contributor.authorFahey, Marie E.
dc.contributor.authorMills, Walter
dc.contributor.authorHiggins, Desmond G.
dc.contributor.authorMoore, Tom
dc.date.accessioned2017-10-03T07:39:01Z
dc.date.available2017-10-03T07:39:01Z
dc.date.issued2004-1-1
dc.identifier.citationMarie E. Fahey, Walter Mills, Desmond G. Higgins, and Tom Moore, “Maternally and Paternally Silenced Imprinted Genes Differ in Their Intron Content,” Comparative and Functional Genomics, vol. 5, no. 8, pp. 572-583, 2004. doi:10.1002/cfg.437
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267524
dc.description.abstractImprinted genes exhibit silencing of one of the parental alleles during embryonic development. In a previous study imprinted genes were found to have reduced intron content relative to a non-imprinted control set (Hurst et al., 1996). However, due to the small sample size, it was not possible to analyse the source of this effect. Here, we re-investigate this observation using larger datasets of imprinted and control (non-imprinted) genes that allow us to consider mouse and human, and maternally and paternally silenced, imprinted genes separately. We find that, in the human and mouse, there is reduced intron content in the maternally silenced imprinted genes relative to a non-imprinted control set. Among imprinted genes, a strong bias is also observed in the distribution of intronless genes, which are found exclusively in the maternally silenced dataset. The paternally silenced dataset in the human is not different to the control set; however, the mouse paternally silenced dataset has more introns than the control group. A direct comparison of mouse maternally and paternally silenced imprinted gene datasets shows that they differ significantly with respect to a variety of intron-related parameters. We discuss a variety of possible explanations for our observations.
dc.rightsAll Rights Reserveden
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved/en
dc.titleMaternally and Paternally Silenced Imprinted Genes Differ in Their Intron Content
dc.typeArticle
dc.date.updated2017-07-13T08:49:49Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderCopyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.identifier.doi10.17863/CAM.13463
rioxxterms.versionofrecord10.1002/cfg.437


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