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dc.contributor.authorSteinbakk, Anita
dc.contributor.authorMalpica, Anais
dc.contributor.authorSlewa, Aida
dc.contributor.authorGudlaugsson, Einar
dc.contributor.authorJanssen, Emiel AM
dc.contributor.authorArends, Mark
dc.contributor.authorKruse, Arnold Jan
dc.contributor.authorYinhua, Yu
dc.contributor.authorFeng, Weiwei
dc.contributor.authorBaak, Jan P
dc.date.accessioned2017-10-03T07:40:15Z
dc.date.available2017-10-03T07:40:15Z
dc.date.issued2010
dc.identifier.citationAnita Steinbakk, Anais Malpica, Aida Slewa, et al., “High Frequency Microsatellite Instability Has a Prognostic Value in Endometrial Endometrioid Adenocarcinoma, But Only in FIGO Stage 1 Cases,” Analytical Cellular Pathology, vol. 33, no. 5-6, pp. 245-255, 2010. doi:10.3233/ACP-CLO-2010-0550
dc.identifier.issn2210-7177
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267549
dc.description.abstractOBJECTIVES: to analyze the prognostic value of microsatellite instability (MSI) in a population-based study of FIGO stage 1-4 endometrial endometrioid adenocarcinomas. STUDY DESIGN: survival analysis in 273 patients of MSI status and clinico-pathologic features. Using a highly sensitive pentaplex polymerase chain reaction to establish MSI status, cases were divided into microsatellite stable (MSS), MSI-low (MSI-L, 1 marker positive) and MSI-high (MSI-H, 2-5 markers positive). RESULTS: after 61 months median follow-up (1-209), 34 (12.5%) of the patients developed metastases but only 6.4% of the FIGO 1. MSI (especially as MSI-H vs. MSS/MSI-Lcombined) was prognostic in FIGO 1 but not in FIGO 2-4. The 5 and 10 year recurrence-free survival rates were 98% and 95% in the MSS/MSI-L vs. 85% and 73% in the MSI-H patients (p=0.005). CONCLUSIONS: MSI-H status assessed by pentaplex polymerase chain reaction is an indicator of poor prognosis in FIGO 1, but not in FIGO 2-4 endometrial endometrioid adenocarcinomas.
dc.publisherHindawi Limited
dc.rightsAll Rights Reserved
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved/
dc.titleHigh frequency microsatellite instability has a prognostic value in endometrial endometrioid adenocarcinoma, but only in FIGO stage 1 cases.
dc.typeArticle
dc.date.updated2017-07-13T08:45:48Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderCopyright © 2010 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
prism.publicationNameAnal Cell Pathol (Amst)
dc.identifier.doi10.17863/CAM.13488
rioxxterms.versionofrecord10.3233/ACP-CLO-2010-0550
dc.identifier.eissn2210-7185


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