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dc.contributor.authorHold, Georgina L.
dc.contributor.authorMukhopadhya, Indrani
dc.contributor.authorMonie, Tom P.
dc.date.accessioned2017-10-03T07:41:40Z
dc.date.available2017-10-03T07:41:40Z
dc.date.issued2011-5-19
dc.identifier.citationGeorgina L. Hold, Indrani Mukhopadhya, and Tom P. Monie, “Innate Immune Sensors and Gastrointestinal Bacterial Infections,” Clinical and Developmental Immunology, vol. 2011, Article ID 579650, 11 pages, 2011. doi:10.1155/2011/579650
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267570
dc.description.abstractThe gastrointestinal microbiota is a major source of immune stimulation. The interaction between host pattern-recognition receptors and conserved microbial ligands profoundly influences infection dynamics. Identifying and understanding the nature of these interactions is a key step towards obtaining a clearer picture of microbial pathogenesis. These interactions underpin a complex interplay between microbe and host that has far reaching consequences for both. Here, we review the role of pattern recognition receptors in three prototype diseases affecting the stomach, the small intestine, and large intestine, respectively (Helicobacter pylori infection, Salmonella infection, and inflammatory bowel disease). Specifically, we review the nature and impact of pathogen:receptor interactions, their impact upon pathogenesis, and address the relevance of pattern recognition receptors in the development of therapies for gastrointestinal diseases.
dc.rightsAll Rights Reserveden
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved/en
dc.titleInnate Immune Sensors and Gastrointestinal Bacterial Infections
dc.typeArticle
dc.date.updated2017-07-13T08:40:59Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderCopyright © 2011 Georgina L. Hold et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.identifier.doi10.17863/CAM.13509
rioxxterms.versionofrecord10.1155/2011/579650


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