Insulin sensitivity assessed by stable isotopes with oral glucose administration: validation with euglycaemic clamp.
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Authors
Bluck, Leslie
Williams, Rachel
Jackson, Sarah
Salgin, Burak
Acerini, Carlo https://orcid.org/0000-0003-2121-5871
Abstract
Methods of determining insulin sensitivity that use an oral challenge of glucose are preferred to those using intravenous administration since the measurement is made in conditions more akin to normal physiology. One previously reported protocol (ODILE) studies glucose uptake in isolation from absorption and endogenous production by the intravenous administration of tracer approximately forty-five minutes after the oral dose is given. However, this methodology has not been validated against other accredited procedures. This study utilizes the euglycemic hyperinsulinemic clamp in order to validate the ODILE method.
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Keywords
1103 Clinical Sciences, Clinical, Clinical Medicine and Science, Diabetes, Dental/Oral and Craniofacial Disease
Journal Title
ISRN Endocrinol
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Journal ISSN
2090-4630
2090-4649
2090-4649
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Publisher
Hindawi Limited