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Neurocognitive functioning in schizophrenia and during the early phases of psychosis: targeting cognitive remediation interventions.


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Type

Article

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Authors

Zaytseva, Yulia 
Korsakova, Natalya 
Agius, Mark 
Gurovich, Isaac 

Abstract

Recent interest in the early course of schizophrenia accentuated altered cognition prior to the onset. Ultrahigh risk (UHR) individuals with attenuated positive symptoms and transient psychotic episodes demonstrate neurocognitive deficits across multiple domains such as memory, executive functioning, and processing speed which are consistent with similar disturbances identified in patients with a first episode of schizophrenia. Cognitive remediation (CR) approaches representing a broad set of activities are aimed to restore or improve cognitive functioning. CR proved to be effective in modulating the cognitive dysfunction in schizophrenia but is rarely used in ultrahigh risk individuals. From the clinical prospective, a better understanding of cognitive functioning in at-risk states is essential for the development of optimal early intervention models. In the review, we highlight the intervention targets, notably the specific cognitive deficits in at risk individuals which preceed the transition to psychosis and emphasize the need of the additional studies using CR approaches in UHR group aiming to enhance cognition and therefore mediate functional improvement.

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Keywords

Adult, Cognition, Cognition Disorders, Disease Progression, Humans, Prospective Studies, Psychotic Disorders, Risk, Schizophrenia

Journal Title

Biomed Res Int

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Journal ISSN

2314-6133
2314-6141

Volume Title

Publisher

Hindawi Limited