Show simple item record

dc.contributor.authorParker, David
dc.date.accessioned2017-10-03T07:46:00Z
dc.date.available2017-10-03T07:46:00Z
dc.date.issued2015-6-11
dc.identifier.citationDavid Parker, “Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses,” Neural Plasticity, vol. 2015, Article ID 512156, 14 pages, 2015. doi:10.1155/2015/512156
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267640
dc.description.abstractThe relevance of neuronal and synaptic variability remains unclear. Cellular and synaptic plasticity and neuromodulation are also variable. This could reflect state-dependent effects caused by the variable initial cellular or synaptic properties or direct variability in plasticity-inducing mechanisms. This study has examined state-dependent influences on synaptic plasticity at connections between excitatory interneurons (EIN) and motor neurons in the lamprey spinal cord. State-dependent effects were examined by correlating initial synaptic properties with the substance P-mediated plasticity of low frequency-evoked EPSPs and the reduction of the EPSP depression over spike trains (metaplasticity). The low frequency EPSP potentiation reflected an interaction between the potentiation of NMDA responses and the release probability. The release probability introduced a variable state-dependent subtractive influence on the postsynaptic NMDA-dependent potentiation. The metaplasticity was also state-dependent: it was greater at connections with smaller available vesicle pools and high initial release probabilities. This was supported by the significant reduction in the number of connections showing metaplasticity when the release probability was reduced by high Mg2+ Ringer. Initial synaptic properties thus introduce state-dependent influences that affect the potential for plasticity. Understanding these conditions will be as important as understanding the subsequent changes.
dc.rightsAll Rights Reserveden
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved/en
dc.titleSynaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses
dc.typeArticle
dc.date.updated2017-07-13T08:28:27Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderCopyright © 2015 David Parker. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.identifier.doi10.17863/CAM.13579
rioxxterms.versionofrecord10.1155/2015/512156


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record