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dc.contributor.authorDe Silva, R. T.
dc.contributor.authorMantilaka, M. M. M. G. P. G.
dc.contributor.authorGoh, K. L.
dc.contributor.authorRatnayake, S. P.
dc.contributor.authorAmaratunga, G. A. J.
dc.contributor.authorde Silva, K. M. Nalin
dc.date.accessioned2017-10-03T07:47:37Z
dc.date.available2017-10-03T07:47:37Z
dc.date.issued2017-6-11
dc.identifier.citationR. T. De Silva, M. M. M. G. P. G. Mantilaka, K. L. Goh, S. P. Ratnayake, G. A. J. Amaratunga, and K. M. Nalin de Silva, “Magnesium Oxide Nanoparticles Reinforced Electrospun Alginate-Based Nanofibrous Scaffolds with Improved Physical Properties,” International Journal of Biomaterials, vol. 2017, Article ID 1391298, 9 pages, 2017. doi:10.1155/2017/1391298
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267665
dc.description.abstractMechanically robust alginate-based nanofibrous scaffolds were successfully fabricated by electrospinning method to mimic the natural extracellular matrix structure which benefits development and regeneration of tissues. Alginate-based nanofibres were electrospun from an alginate/poly(vinyl alcohol) (PVA) polyelectrolyte complex. SEM images revealed the spinnability of the complex composite nanofibrous scaffolds, showing randomly oriented, ultrafine, and virtually defects-free alginate-based/MgO nanofibrous scaffolds. Here, it is shown that an alginate/PVA complex scaffold, blended with near-spherical MgO nanoparticles (⌀ 45 nm) at a predetermined concentration (10% (w/w)), is electrospinnable to produce a complex composite nanofibrous scaffold with enhanced mechanical stability. For the comparison purpose, chemically cross-linked electrospun alginate-based scaffolds were also fabricated. Tensile test to rupture revealed the significant differences in the tensile strength and elastic modulus among the alginate scaffolds, alginate/MgO scaffolds, and cross-linked alginate scaffolds (). In contrast to cross-linked alginate scaffolds, alginate/MgO scaffolds yielded the highest tensile strength and elastic modulus while preserving the interfibre porosity of the scaffolds. According to the thermogravimetric analysis, MgO reinforced alginate nanofibrous scaffolds exhibited improved thermal stability. These novel alginate-based/MgO scaffolds are economical and versatile and may be further optimised for use as extracellular matrix substitutes for repair and regeneration of tissues.
dc.rightsAll Rights Reserveden
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved/en
dc.titleMagnesium Oxide Nanoparticles Reinforced Electrospun Alginate-Based Nanofibrous Scaffolds with Improved Physical Properties
dc.typeArticle
dc.date.updated2017-07-11T12:47:08Z
dc.description.versionPeer Reviewed
dc.language.rfc3066en
dc.rights.holderCopyright © 2017 R. T. De Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.identifier.doi10.17863/CAM.13604
rioxxterms.versionofrecord10.1155/2017/1391298


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