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dc.contributor.authorDoorbar, Johnen
dc.date.accessioned2017-10-03T09:57:59Z
dc.date.available2017-10-03T09:57:59Z
dc.identifier.issn1521-6934
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267673
dc.description.abstractMost human papillomaviruses cause inapparent infections, subtly affecting epithelial homeostasis, to ensure genome persistence in the epithelial basal layer. As with conspicuous papillomas, these self-limiting lesions shed viral particles to ensure population level maintenance and depend on a balance between viral gene expression, immune cell stimulation and immune surveillance for persistence. The complex immune evasion strategies, characteristic of high-risk HPV types, also allow the deregulated viral gene expression that underlies neoplasia. Neoplasia occurs at particular epithelial sites where vulnerable cells such as the reserve or cuboidal cells of the cervical transformation zone are found. Beta papillomavirus infection can also predispose an individual with immune deficiencies to the development of cancers. The host control of HPV infections thus involves local interactions between keratinocytes and the adaptive immune response. Effective immune detection and surveillance limits overt disease, leading to HPV persistence as productive microlesions or in a true latent state.
dc.description.sponsorshipSupport by the Medical Research Council (programme grant U117584278) has allowed the formulation of many of the ideas outlined in this review.
dc.language.isoenen
dc.publisherElsevier
dc.subjectpapillomavirusen
dc.subjectepithelial homeostasisen
dc.subjectwarten
dc.subjectCINen
dc.subjectHPVen
dc.titleHost control of human papillomavirus infection and diseaseen
dc.typeArticle
prism.publicationNameBest Practice & Research Clinical Obstetrics & Gynaecologyen
dc.identifier.doi10.17863/CAM.13611
dcterms.dateAccepted2017-08-07en
rioxxterms.versionofrecord10.1016/j.bpobgyn.2017.08.001en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-08-07en
dc.contributor.orcidDoorbar, John [0000-0002-4027-102X]
dc.identifier.eissn1532-1932
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMRC (MC_PC_13050)
pubs.funder-project-idMedical Research Council (MC_U117584278)
cam.issuedOnline2017-08-12en
rioxxterms.freetoread.startdate2018-08-12


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