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dc.contributor.authorRulands, Sen
dc.contributor.authorSimons, Benjaminen
dc.date.accessioned2017-10-03T10:50:21Z
dc.date.available2017-10-03T10:50:21Z
dc.date.issued2017-10en
dc.identifier.issn2452-3100
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267680
dc.description.abstractThe mechanisms that control cell fate behaviour during development, and the factors leading to their dysregulation in disease, remain the subject of interest and debate. Lately, advances in single-cell genomics have shifted emphasis towards the elucidation of molecular regulatory programmes and transcriptional cell states. However, quantitative statistical approaches based on cell lineage tracing data have provided fresh insight into stem and progenitor cell behaviour, questioning the role of cell fate stochasticity, transcriptional heterogeneity and state priming. These investigations, which draw upon conceptual insights from statistical physics and mathematics, provide a novel, generic and rigorous framework to resolve and classify stem cell self-renewal strategies, which heavily constrain, but do not seek to define, underlying molecular mechanistic programmes. Here, using epithelial maintenance as an exemplar, we consider the foundation, conceptual basis, utility and limitations of such quantitative approaches in cell biology.
dc.description.sponsorshipB.D.S. acknowledges the support of the Wellcome Trust (grant number 098357/Z/12/Z) and the core funding to the Gurdon Institute by the Wellcome Trust and Cancer Research UK.
dc.language.isoenen
dc.publisherElsevier
dc.titleEmergence and universality in the regulation of stem cell fateen
dc.typeArticle
prism.endingPage62
prism.publicationDate2017en
prism.publicationNameCurrent Opinion in Systems Biologyen
prism.startingPage57
prism.volume5en
dc.identifier.doi10.17863/CAM.12466
dcterms.dateAccepted2017-08-01en
rioxxterms.versionofrecord10.1016/j.coisb.2017.08.001en
rioxxterms.versionAMen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-10en
dc.contributor.orcidSimons, Benjamin [0000-0002-3875-7071]
dc.identifier.eissn2452-3100
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idWELLCOME TRUST (098357/Z/12/Z)
pubs.funder-project-idWellcome Trust (097922/Z/11/Z)
cam.issuedOnline2017-08-09en
rioxxterms.freetoread.startdate2018-10-03


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