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dc.contributor.authorCho, Jungnamen
dc.contributor.authorPaszkowski, Jerzyen
dc.date.accessioned2017-10-16T09:54:32Z
dc.date.available2017-10-16T09:54:32Z
dc.date.issued2017-08-26en
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267850
dc.description.abstractIt is well documented that transposable elements (TEs) can regulate the expression of neighbouring genes. However, their ability to act in trans and influence ectopic loci has been reported rarely. We searched in rice transcriptomes for tissue-specific expression of TEs and found them to be regulated developmentally. They often shared sequence homology with co-expressed genes and contained potential microRNA-binding sites, which suggested possible contributions to gene regulation. In fact, we have identified a retrotransposon that is highly transcribed in roots and whose spliced transcript constitutes a target mimic for miR171. miR171 destabilizes mRNAs encoding the root-specific family of SCARECROW-Like transcription factors. We demonstrate that retrotransposon-derived transcripts act as decoys for miR171, triggering its degradation and thus results in the root-specific accumulation of SCARECROW-Like mRNAs. Such transposon-mediated post-transcriptional control of miR171 levels is conserved in diverse rice species.
dc.description.sponsorshipThis work was supported by European Research Council 492 (EVOBREED) [322621]; Gatsby Fellowship [AT3273/GLE].
dc.language.isoenen
dc.publishereLife Sciences Publications Ltd
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleRegulation of rice root development by a retrotransposon acting as a microRNA spongeen
dc.typeArticle
prism.numbere30038en
prism.publicationDate2017en
prism.publicationNameeLifeen
prism.volume6en
dc.identifier.doi10.17863/CAM.13770
dcterms.dateAccepted2017-08-21en
rioxxterms.versionofrecord10.7554/eLife.30038en
rioxxterms.versionVoRen
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en
rioxxterms.licenseref.startdate2017-08-26en
dc.contributor.orcidCho, Jungnam [0000-0002-4078-7763]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEuropean Research Council (322621)
pubs.funder-project-idGatsby Charitable Foundation (unknown)
cam.issuedOnline2017-08-26en
cam.orpheus.successThu Jan 30 13:00:45 GMT 2020 - The item has an open VoR version.*
rioxxterms.freetoread.startdate2100-01-01


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International