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Challenges and discoveries in the total synthesis of complex polyketide natural products

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Lam, NYS 

Abstract

Structurally complex polyketide natural products, isolated from a variety of marine and terrestrial sources, continue to provide a valuable source of rewarding targets for the synthetic chemist to tackle. In this account, we provide an overview of the total synthesis of several structurally fascinating polyketides with promising anticancer activity completed in our group based on our versatile asymmetric aldol methodology—spirastrellolide A methyl ester, leiodermatolide, rhizopodin and chivosazole F—and highlight the unanticipated challenges and discoveries encountered.

Description

Keywords

Animals, Antibiotics, Antineoplastic, Biological Products, Drug Discovery, Humans, Polyketide Synthases, Polyketides

Journal Title

Journal of Antibiotics

Conference Name

Journal ISSN

0021-8820
1881-1469

Volume Title

Publisher

Springer Science and Business Media LLC