Challenges and discoveries in the total synthesis of complex polyketide natural products
Accepted version
Peer-reviewed
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Repository DOI
Change log
Authors
Paterson, Ian https://orcid.org/0000-0002-8861-9136
Lam, NYS
Abstract
Structurally complex polyketide natural products, isolated from a variety of marine and terrestrial sources, continue to provide a valuable source of rewarding targets for the synthetic chemist to tackle. In this account, we provide an overview of the total synthesis of several structurally fascinating polyketides with promising anticancer activity completed in our group based on our versatile asymmetric aldol methodology—spirastrellolide A methyl ester, leiodermatolide, rhizopodin and chivosazole F—and highlight the unanticipated challenges and discoveries encountered.
Description
Keywords
Animals, Antibiotics, Antineoplastic, Biological Products, Drug Discovery, Humans, Polyketide Synthases, Polyketides
Journal Title
Journal of Antibiotics
Conference Name
Journal ISSN
0021-8820
1881-1469
1881-1469
Volume Title
Publisher
Springer Science and Business Media LLC