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dc.contributor.authorEveritt, Barry Johnen
dc.contributor.authorGiuliano, Chiaraen
dc.contributor.authorBelin, Daviden
dc.date.accessioned2017-10-30T18:10:52Z
dc.date.available2017-10-30T18:10:52Z
dc.date.issued2018-03-19en
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/267980
dc.description.abstractSince the introduction of intravenous drug self-administration methodology over 50 years ago, experimental investigation of addictive behaviour has delivered an enormous body of data on the neural, psychological and molecular mechanisms of drug reward and reinforcement and the neuroadaptations to chronic use. Whether or not these behavioural and molecular studies are viewed as modelling the underpinnings of addiction in humans, the discussion presented here highlights two areas—the impact of drug-associated conditioned stimuli—or drug cues—on drug seeking and relapse, and compulsive cocaine seeking. The degree to which these findings translate to the clinical state of addiction is considered in terms of the underlying neural circuitry and also the ways in which this understanding has helped develop new treatments for addiction. The psychological and neural mechanisms underlying drug memory reconsolidation and extinction established in animal experiments show particular promise in delivering new treatments for relapse prevention to the clinic.
dc.description.sponsorshipThe research presented here was funded by the Medical Research Council (RG82507).
dc.publisherRoyal Society Publishing
dc.subjectaddictionen
dc.subjectcompulsionen
dc.subjecthabitsen
dc.subjectmemoryen
dc.subjectreconsolidationen
dc.subjectextinctionen
dc.titleAddictive behaviour in experimental animals: prospects for translationen
dc.typeArticle
prism.issueIdentifier1742en
prism.publicationDate2018en
prism.publicationNamePhilosophical Transactions of the Royal Society B: Biological Sciencesen
prism.volume373en
dc.identifier.doi10.17863/CAM.13908
dcterms.dateAccepted2017-08-30en
rioxxterms.versionofrecord10.1098/rstb.2017-0027en
rioxxterms.versionAM*
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2018-03-19en
dc.contributor.orcidEveritt, Barry John [0000-0003-4431-6536]
dc.contributor.orcidBelin, David [0000-0002-7383-372X]
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idMedical Research Council (G1002231)
pubs.funder-project-idMedical Research Council (G0600196)
pubs.funder-project-idMedical Research Council (MR/N02530X/1)
cam.issuedOnline2018-01-19en


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