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dc.contributor.authorCope, Thomasen
dc.contributor.authorRittman, Timothyen
dc.contributor.authorBorchert, Ren
dc.contributor.authorJones, Simonen
dc.contributor.authorVatansever, Denizen
dc.contributor.authorAllinson, Ken
dc.contributor.authorPassamonti, Lucaen
dc.contributor.authorVazquez Rodriguez, Pen
dc.contributor.authorBevan-Jones, Williamen
dc.contributor.authorO'Brien, Johnen
dc.contributor.authorRowe, Jamesen
dc.description.abstractAlzheimer’s Disease (AD) and Progressive Supranuclear Palsy (PSP) represent neurodegenerative Tauopathies with predominantly cortical vs subcortical disease burden. In AD, neuropathology and atrophy preferentially affect ‘hub’ brain regions that are densely connected. It was unclear whether hubs are differentially affected by neurodegeneration because they are more likely to receive pathological proteins that propagate trans-neuronally, in a prion-like manner, or whether they are selectively vulnerable due to a lack of local trophic factors, higher metabolic demands, or differential gene expression. We assessed the relationship between Tau burden and brain functional connectivity, by combining in vivo PET imaging using the ligand AV-1451, and graph theoretic measures of resting-state fMRI in 17 patients with AD, 17 patients with PSP, and 12 controls. Strongly connected nodes displayed more Tau pathology in AD, independently of intrinsic connectivity network, validating the predictions of theories of trans-neuronal spread but not supporting a role for metabolic demands or deficient trophic support in Tau accumulation. This was not a compensatory phenomenon, as the functional consequence of increasing Tau burden in AD was a progressive weakening of the connectivity of these same nodes, reducing weighted degree and local efficiency and resulting in weaker ‘small-world’ properties. Conversely, in PSP, unlike in AD, those nodes that accrued pathological Tau were those that displayed graph metric properties associated with increased metabolic demand and a lack of trophic support rather than strong functional connectivity. Together, these findings go some way towards explaining why AD affects large scale connectivity networks throughout cortex while neuropathology in PSP is concentrated in a small number of subcortical structures. Further, we demonstrate that in PSP increasing Tau burden in midbrain and deep nuclei was associated with strengthened cortico-cortical functional connectivity. Disrupted cortico-subcortical and cortico-brainstem interactions meant that information transfer took less direct paths, passing through a larger number of cortical nodes, reducing closeness centrality and eigenvector centrality in PSP, while increasing weighted degree, clustering, betweenness centrality and local efficiency. Our results have wide-ranging implications, from the validation of models of Tau trafficking in humans to understanding the relationship between regional Tau burden and brain functional reorganization.
dc.description.sponsorshipThe NIMROD study was funded by the National Institute for Health Research (NIHR, RG64473) Cambridge Biomedical Research Centre and Biomedical Research Unit in Dementia, PSP Association, the Wellcome Trust (JBR 103838), the Medical Research Council (MC-A060-5PQ30). T.E.C. is supported by a personal fellowship from the Association of British Neurologists and Patrick Berthoud charitable trust.
dc.rightsAttribution 4.0 International
dc.rightsAttribution 4.0 Internationalen
dc.subjectAlzheimer's Diseaseen
dc.subjectProgressive Supranuclear Palsyen
dc.subjectFunctional Connectivityen
dc.subjectGraph Theoryen
dc.titleTau Burden and the Functional Connectome in Alzheimer's Disease and Progressive Supranuclear Palsyen
dc.contributor.orcidCope, Thomas [0000-0002-4751-1786]
dc.contributor.orcidRittman, Timothy [0000-0003-1063-6937]
dc.contributor.orcidJones, Simon [0000-0001-9695-0702]
dc.contributor.orcidVatansever, Deniz [0000-0002-2494-9945]
dc.contributor.orcidPassamonti, Luca [0000-0002-7937-0615]
dc.contributor.orcidO'Brien, John [0000-0002-0837-5080]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idAssociation of British Neurologists (ABN) (unknown)
pubs.funder-project-idWELLCOME TRUST (103838/Z/14/Z)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idMedical Research Council (MC_U105597119)
pubs.funder-project-idMedical Research Council (G1100464)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/M009041/1)
pubs.funder-project-idMEDICAL RESEARCH COUNCIL (MR/M024873/1)
cam.orpheus.successThu Jan 30 12:59:07 GMT 2020 - The item has an open VoR version.*

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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International